Synthesis and biological evaluation of some functionalized 1H-1,2,3-triazole tethered pyrazolo[3,4-b]pyridin-6(7H)-ones as antimicrobial and apoptosis inducing agents

被引：0
作者：
Jayant Sindhu
Harjinder Singh
J. M. Khurana
Jitender Kumar Bhardwaj
Priyanka Saraf
Chetan Sharma
机构：
[1] University of Delhi,Department of Chemistry
[2] Kurukshetra University Kurukshetra,Reproductive Physiology Laboratory, Department of Zoology
[3] MMU,Department of Biotechnology
来源：
Medicinal Chemistry Research | 2016年 / 25卷
关键词：
Apoptosis; Ovarian follicles; One-pot; 1,2,3-triazoles; Pyrazole; Antimicrobial; Click chemistry; Multicomponent; Green;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of novel molecular hybrids containing pyrazole, pyridinone and 1,2,3-triazoles have been synthesized by one-pot four-component reaction of Meldrum’s acid, substituted aryl azides, 4-(prop-2-yn-1-yloxy)aryl aldehyde and 3-methyl-1-phenyl-1H-pyrazol-5-amine using L-proline as a basic organocatalyst besides CuSO4.5H2O and sodium ascorbate as catalysts for click chemistry in PEG-400 as a highly efficient and green media. Apoptosis studies have been carried out on ovarian follicles of goat (Capra hircus) and in vitro antibacterial activity has been done against six strains namely Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa and antifungal activity against two yeast strains namely, Candida albicans and Saccharomyces cerevisiae.
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页码：1813 / 1830
页数：17
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