Oestrogen exposure and breast cancer risk

被引：0
作者：
Ruth C Travis
Timothy J Key
机构：
[1] University of Oxford,Cancer Research UK, Epidemiology Unit
来源：
Breast Cancer Research | / 5卷
关键词：
breast cancer; epidemiology; oestrogen; prevention; risk factors;
D O I：
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摘要：
Epidemiological and experimental evidence implicates oestrogens in the aetiology of breast cancer. Most established risk factors for breast cancer in humans probably act through hormone-related pathways, and increased concentrations of circulating oestrogens have been found to be strongly associated with increased risk for breast cancer in postmenopausal women. This article explores the evidence for the hypothesis that oestrogen exposure is a major determinant of risk for breast cancer. We review recent data on oestrogens and breast cancer risk, consider oestrogen-related risk factors and examine possible mechanisms that might account for the effects of oestrogen. Finally, we discuss how these advances might influence strategies for reducing the incidence of breast cancer.
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[1]  
Pike MC(1993)Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk Epidemiol Rev 15 17-35
[2]  
Spicer DV(2002)Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies J Natl Cancer Inst 94 606-616
[3]  
Dahmoush L(2003)Overview of the main outcomes in breast-cancer prevention trials Lancet 361 296-300
[4]  
Press MF(2003)The role of prolactin in mammary carcinoma Endocr Rev 24 1-27
[5]  
Cuzick J(2003)The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer Breast Cancer Res 5 164-173
[6]  
Powles T(1997)Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer Lancet 350 1047-1059
[7]  
Veronesi U(2002)Hereditary breast cancer and handling of patients at risk Scand J Surg 91 280-287
[8]  
Forbes J(1997)Non-dietary factors as risk factors for breast cancer, and as effect modifiers of the association of fat intake and risk of breast cancer Cancer Causes Control 8 49-56
[9]  
Edwards R(2001)Epidemiology of breast cancer Lancet Oncol 2 133-140
[10]  
Ashley S(2002)Transient increase in breast cancer risk after giving birth: postpartum period with the highest risk (Sweden) Cancer Causes Control 13 299-305
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