Changes in total choline concentration in the breast of healthy fertile young women in relation to menstrual cycle or use of oral contraceptives: a 3-T 1H-MRS study

被引：1

作者：

Di Leo G. ^{[1
]}

Ioan I. ^{[2
]}

Luciani M.L. ^{[3
]}

Midulla C. ^{[3
]}

Podo F. ^{[4
]}

Sardanelli F. ^{[1
,5
]}

Pediconi F. ^{[3
]}

机构：

[1] Radiology Unit, IRCCS Policlinico San Donato, San Donato Milanese

[2] Postgraduate School in Radiodiagnostics, Università degli Studi di Milano, Milan

[3] Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome

[4] Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome

[5] Department of Biomedical Sciences for Health, Università degli Studi di Milano, San Donato Milanese

来源：

European Radiology Experimental | / 2卷 / 1期

关键词：

Breast; Choline; Contraceptives (oral); Magnetic resonance spectroscopy; Menstrual cycle;

D O I：

10.1186/s41747-018-0075-0

中图分类号：

学科分类号：

摘要：

Background: To evaluate changes in total choline (tCho) absolute concentration ([tCho]) in the breast of healthy fertile women in relation to menstrual cycle (MC) or use of oral contraceptives (OC). Methods: After institutional review board approval, we prospectively evaluated 40 healthy fertile volunteers: 20 with physiological MC, aged 28 ± 3 years (mean ± standard deviation; nOC group); 20 using OC, aged 26 ± 3 years (OC group). Hormonal assays and water-suppressed single-voxel 3-T proton magnetic resonance spectroscopy (1H-MRS) were performed on MC days 7, 14, and 21 in the nOC group and only on MC day 14 in the OC group. [tCho] was measured versus an external phantom. Mann-Whitney U test and Spearman coefficient were used; data are given as median and interquartile interval. Results: All spectra had good quality. In the nOC group, [tCho] (mM) did not change significantly during MC: 0.8 (0.3–2.4) on day 7, 0.9 (0.4–1.2) on day 14, and 0.4 (0.2–0.8) on day 21 (p = 0.963). In the OC group, [tCho] was 0.7 (0.2–1.7) mM. The between-groups difference was not significant on all days (p ≥ 0.411). All hormones except prolactin changed during MC (p ≤ 0.024). In the OC group, [tCho] showed a borderline correlation with estradiol (r = 0.458, p = 0.056), but no correlation with other hormones (p ≥ 0.128). In the nOC group, [tCho] negatively correlated with prolactin (r = -0.587, p = 0.006) on day 7; positive correlation was found with estradiol on day 14 (r = 0.679, p = 0.001). Conclusions: A tCho peak can be detected in the normal mammary gland using 3-T 1H-MRS. The [tCho] in healthy volunteers was 0.4–0.9 mM, constant over the MC and independent of OC use. © 2018, The Author(s).

引用

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