Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2

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作者：
Joshua M. Levy
Jennifer K. Frediani
Erika A. Tyburski
Anna Wood
Janet Figueroa
Russell R. Kempker
Paulina A. Rebolledo
Mark D. Gonzalez
Julie Sullivan
Miriam B. Vos
Jared O’Neal
Greg S. Martin
Wilbur A. Lam
Jesse J. Waggoner
机构：
[1] The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies,Department of Otolaryngology
[2] Emory University School of Medicine,Head and Neck Surgery
[3] Nell Hodgson Woodruff School of Nursing,Department of Medicine
[4] Emory University,Rollins School of Public Health
[5] Georgia Institute of Technology,Department of Pediatrics
[6] Emory University School of Medicine,Department of Pathology and Laboratory Medicine
[7] Emory University,Wallace H. Coulter Department of Biomedical Engineering
[8] Emory University School of Medicine,undefined
[9] Children’s Healthcare of Atlanta,undefined
[10] Emory University School of Medicine,undefined
[11] Aflac Cancer & Blood Disorders Center at Children’s Healthcare of Atlanta,undefined
[12] Emory University and Georgia Institute of Technology,undefined
来源：
Scientific Reports | / 11卷
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摘要：
The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 testing in Atlanta, GA. High concordance was found between consecutively collected mid-turbinate samples with both molecular (n = 74, 100% concordance) and antigen-based (n = 147, 97% concordance, kappa = 0.95, CI = 0.88–1.00) diagnostic assays. Repeated sample collection does not decrease COVID-19 test performance, demonstrating that multiple samples can be collected for assay validation and clinical diagnosis.
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