Terpenoids from Vitex trifolia and their anti-inflammatory activities

被引：0
作者：
Fengyan Bao
Ruotian Tang
Li Cheng
Cuiyun Zhang
Chongyue Qiu
Ting Yuan
Lihan Zhu
Hua Li
Lixia Chen
机构：
[1] Shenyang Pharmaceutical University,Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure
[2] Huazhong University of Science and Technology,Based Drug Design & Discovery, Ministry of Education
来源：
Journal of Natural Medicines | 2018年 / 72卷
关键词：
L.; Diterpenoid; Iridoid; Anti-inflammatory effect;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new diterpenoid glucoside, (3S,5S,6S,8R,9R,10S)-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3-O-β-D-glucopyranoside (1), and a new iridoid glucoside, (1S, 5S,6R,9R)-10-O-p-hydroxybenzoyl-5,6β-dihydroxy iridoid 1-O-β-D-glucopyranoside (2), along with six known compounds (3-8) were isolated from Vitex trifolia L.. Their structures were elucidated by extensive spectroscopic analysis. All these isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophages. Compounds 2, 4, 5, and 7 showed moderate inhibitory activities with IC50 values of 90.05, 88.51, 87.26, and 76.06 μM, respectively.
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页码：570 / 575
页数：5
相关论文
共 117 条
[1]  
Ono M(2000)Diterpenoids from the fruits of Phytochemistry 55 873-877
[2]  
Sawamura H(2013)A new taraxastane-type triterpene from Helv Chim Acta 96 2040-2045
[3]  
Ito Y(2007)New antifungal flavonoid glycoside from Bioorg Med Chem Lett 17 239-242
[4]  
Mizuki K(2002)Vitexlactam A, a novel labdane diterpene lactam from the fruits of Tetrahedron Lett 43 5131-5134
[5]  
Nohara T(2001)- Chem Pharm Bull 49 82-86
[6]  
Huang MY(1997)Ten new labdane-type diterpenes from the fruit of Phytochemistry 48 1149-1152
[7]  
Zhong LJ(1995)Ecdysteroids of the root bark of Phytochemistry 38 473-476
[8]  
Xie JM(2004)Ecdysteroids from J Nat Prod 67 2012-2016
[9]  
Wang F(2016)New acylated iridoid glucosides from Molecules 21 1179-1198
[10]  
Zhang YH(2001)A review on the terpenes from genus J Ethnopharmacol 75 249-256
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