Characterizations of doxorubicin-loaded PEGylated magnetic liposomes for cancer cells therapy

被引：0
作者：
Andri Hardiansyah
Fredina Destyorini
Yuyun Irmawati
Ming-Chien Yang
Chi-Ming Liu
Elsy Rahimi Chaldun
Ming-Chi Yung
Ting Yu Liu
机构：
[1] Indonesian Institute of Sciences,Research Center for Physics
[2] National Taiwan University of Science and Technology,Department of Materials Science and Engineering
[3] Ming Chi University of Technology,Department of Materials Engineering
[4] Indonesian Institute of Sciences,Research Unit for Clean Technology
[5] Taipei Medical University Hospital,Division of Cardiovascular Surgery, Department of Surgery, School of Medicine
来源：
Journal of Polymer Research | 2019年 / 26卷
关键词：
Poly-(ethylene glycol); Liposomes; Magnetic nanoparticles; Doxorubicin; Cytocompatibility;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Magnetic-guided drug delivery system for cancer treatment can be realized by elaborating drug and magnetic nanoparticles (MNP) on the liposomes through the assistance of magnetic field exposure. Here, we prepared PEGylated liposomes (liposomes with poly-(ethylene glycol) (PEG) modification) to encapsulate doxorubicin (DOX) and MNP, termed as DOX-loaded PEGylated magnetic liposomes. We show that the DOX-loaded PEGylated magnetic liposomes exhibits spherical morphology with diameter about 100 nm, dispersed homogeneously in aqueous system and generate inductive heating from 37o to 56 °C by means of high-frequency magnetic field (HFMF) exposure. Moreover, DOX could kill HeLa cells due to DOX releasing indicating the DOX cytotoxicity to the HeLa cells as a function of DOX concentration. In conclusion, these liposomes could combine the function of DOX and MNP, opening a route as a drug carrier platform to enhance the therapeutic efficacy of chemotherapeutic drug and it could be integrated with the development of magnetic-guided drug delivery.
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