Effect of Liposome-Encapsulated Zoledronic Acid on Microenvironment of Hepatocellular Carcinoma May Depend on the Ratio Between M1 and M2 Polarized Macrophages

被引：0
作者：
S. Wu
X. Lin
X. Cui
机构：
[1] the First Affiliated Hospital of Hainan Medical University,Department of Ultrasound
[2] the First Affiliated Hospital of Hainan Medical University,Department of Emergency Medicine
来源：
Bulletin of Experimental Biology and Medicine | 2020年 / 170卷
关键词：
tumor-associated macrophages (TAMs); zoledronic acid; liposome; hepatocellular carcinoma;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We studied the effect of zoledronic acid encapsulated into liposomes (L-ZOL) on tumorassociated macrophages in the stroma of hepatocellular carcinoma xenograft. Liposomes were prepared from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-snglycero-3-phospho-sn-1-glycerol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] using thin film method and loaded with zoledronic acid. It was shown that L-ZOL promoted apoptosis of RAW264.7 cells, eliminate much more protumoral M2 macrophages than antitumoral M1 macrophages in the tumor xenograft, and did not significantly reduce the size of xenograft in 6 days. Thus, the effect of treatment depends on the ratio between antitumoral M1 and protumoral M2 polarized macrophages in the tumor.
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页码：69 / 74
页数：5
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