GC-ECD Determination of Lindane and Its Impurity α-HCH in Pharmaceutical Products

A method was developed to determine lindane (γ-HCH), the widely used organochlorine pesticide, and its impurity α-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully resolve the lindane peak from α-HCH and interfering components. The method displays an excellent linearity over the concentration range 0.5–15.0 μg mL−1 for lindane and 0.005–0.15 μg mL−1 for α-HCH and a precision better than 2.5% from intra- and inter-day analyses. LOQ and LOD were determined to be 0.45 and 0.15 μg mL−1 for lindane and 0.005 and 0.002 μg mL−1 for α-HCH.