Biocondensates fuel tumor immune evasion

被引：0
|
作者：
Kelsey P. Kubelick
Felipe Garcia Quiroz
机构：
[1] Georgia Institute of Technology and Emory University,Wallace H. Coulter Department of Biomedical Engineering
[2] Georgia Institute of Technology,School of Electrical and Computer Engineering
来源：
Nature Cancer | 2023年 / 4卷
关键词：
D O I：
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学科分类号：
摘要：
Transactivation hubs and related biomolecular condensates are emerging as relevant molecular players in cancer biology. A new study now links PD-L1 upregulation on the cancer cell surface and IRF1–KAT8 transactivation hubs at PD-L1 loci. Therapeutic targeting of these hubs holds potential to unleash antitumor immunity.
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页码：312 / 314
页数：2
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