Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6

Barzilai N(2016)Metformin as a tool to target aging Cell Metab 23 1060-1065

Crandall JP(2020)Benefits of metformin in attenuating the hallmarks of aging Cell Metab 32 15-30

Kritchevsky SB(2016)Metabolic control of longevity Cell 166 802-821

Espeland MA(2017)Metformin ameliorates core deficits in a mouse model of fragile X syndrome Nat Med 23 674-677

Kulkarni AS(2013)Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation Aging Cell 12 489-498

Gubbi S(2010)Metformin supplementation and life span in Fischer-344 rats J Gerontol A Biol Sci Med Sci 65A 468-474

Barzilai N(2020)Shengyu Feng, Ce Huang, Zhongmin Liu, Yi Eve Sun, Hailiang Liu: Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis Aging 12 1-18

Lopez-Otin C(2018)Metformin alters upper small intestinal microbiota that impact a glucose-SGLT1-sensing glucoregulatory pathway Cell Metab 27 101-117.e105

Galluzzi L(2015)Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota Nature 528 262-266

Freije JMP(2017)Metformin is associated with higher relative abundance of mucin-degrading Akkermansia muciniphila and several short-chain fatty acid–producing microbiota in the gut Diabetes Care 40 54-62

Barzilai N(2016)Metformin as a tool to target aging Cell Metab 23 1060-1065

Crandall JP(2020)Benefits of metformin in attenuating the hallmarks of aging Cell Metab 32 15-30

Kritchevsky SB(2016)Metabolic control of longevity Cell 166 802-821

Espeland MA(2017)Metformin ameliorates core deficits in a mouse model of fragile X syndrome Nat Med 23 674-677

Kulkarni AS(2013)Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation Aging Cell 12 489-498

Gubbi S(2010)Metformin supplementation and life span in Fischer-344 rats J Gerontol A Biol Sci Med Sci 65A 468-474

Barzilai N(2020)Shengyu Feng, Ce Huang, Zhongmin Liu, Yi Eve Sun, Hailiang Liu: Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis Aging 12 1-18

Lopez-Otin C(2018)Metformin alters upper small intestinal microbiota that impact a glucose-SGLT1-sensing glucoregulatory pathway Cell Metab 27 101-117.e105

Galluzzi L(2015)Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota Nature 528 262-266

Freije JMP(2017)Metformin is associated with higher relative abundance of mucin-degrading Akkermansia muciniphila and several short-chain fatty acid–producing microbiota in the gut Diabetes Care 40 54-62