The emergence of molecular machines as a prerequisite of the ancient RNA world evolution

被引：0
作者：
A. S. Spirin
机构：
[1] Russian Academy of Sciences,Institute of Protein Research
来源：
Paleontological Journal | 2013年 / 47卷
关键词：
evolution; helicases; molecular machines; polymerases; polyribonucleotides; ribozymes; RNA word;
D O I：
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学科分类号：
摘要：
The problem of the start of biological evolution in the ancient RNA world is considered. It is postulated that the appearance of catalytic RNAs — ribozymes — via spontaneous cis- and trans-rearrangements of polyribonucleotides in primordial Darwin ponds should not have been sufficient for the start of evolution, until a new class of functional RNA, namely energy-dependent molecular machines, arose. The proposed hypothesis is that the simplest and primary type of molecular machines could be nucleoside triphosphate-dependent RNA-based helicases, which were capable of unwinding the stable double-helical RNAs inevitably formed during RNA syntheses on complementary templates. Thereupon, unwinding RNA polymerases could appear as a result of association or fusion of helicases and polyribonucleotide-polymerizing ribozymes. The latter event provided the mechanism of RNA replication using the double-helical RNAs as a communal genofond (gene pool) of a Darwin pond, and thus initiated the fast evolution of the ancient RNA world.
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页码：1016 / 1029
页数：13
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