Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped

[11] Turner RC(2020)Glucolipotoxicity, beta-cells, and diabetes: the emperor has no clothes Diabetes 69 273-278

[12] Cull CA(2016)Stress-impaired transcription factor expression and insulin secretion in transplanted human islets J Clin Invest 126 1857-1870

[13] Frighi V(2020)Persistent or transient human β cell dysfunction induced by metabolic stress: specific signatures and shared gene expression with type 2 diabetes Cell Rep 33 108466-108466

[14] Holman RR(2011)Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol Diabetologia 54 2506-2514

[15] Andersson A(2018)Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for beta cell recovery Cell Metab 28 547-556

[16] Hellerstrom C(2017)NADPH oxidase-2 does not contribute to beta-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice Mol Cell Endocrinol 439 354-362

[17] van Raalte DH(2020)Nutrient metabolism, subcellular redox state, and oxidative stress in pancreatic islets and beta-cells J Mol Biol 432 1461-1493

[18] Diamant M(1996)Stable and diffusible pools of nucleotides in pancreatic islet cells Endocrinology 137 4671-4676

[19] Bensellam M(2004)Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose Am J Physiol Endocrinol Metab 287 E207-E217

[20] Laybutt DR(2021)Dynamic uni- and multicellular patterns encode biphasic activity in pancreatic islets Diabetes 70 878-888

[11] Turner RC(2020)Glucolipotoxicity, beta-cells, and diabetes: the emperor has no clothes Diabetes 69 273-278

[12] Cull CA(2016)Stress-impaired transcription factor expression and insulin secretion in transplanted human islets J Clin Invest 126 1857-1870

[13] Frighi V(2020)Persistent or transient human β cell dysfunction induced by metabolic stress: specific signatures and shared gene expression with type 2 diabetes Cell Rep 33 108466-108466

[14] Holman RR(2011)Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol Diabetologia 54 2506-2514

[15] Andersson A(2018)Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for beta cell recovery Cell Metab 28 547-556

[16] Hellerstrom C(2017)NADPH oxidase-2 does not contribute to beta-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice Mol Cell Endocrinol 439 354-362

[17] van Raalte DH(2020)Nutrient metabolism, subcellular redox state, and oxidative stress in pancreatic islets and beta-cells J Mol Biol 432 1461-1493

[18] Diamant M(1996)Stable and diffusible pools of nucleotides in pancreatic islet cells Endocrinology 137 4671-4676

[19] Bensellam M(2004)Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose Am J Physiol Endocrinol Metab 287 E207-E217

[20] Laybutt DR(2021)Dynamic uni- and multicellular patterns encode biphasic activity in pancreatic islets Diabetes 70 878-888