Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped

[1] Henquin JC(2006)Nutrient control of insulin secretion in isolated normal human islets Diabetes 55 3470-3477

[2] Dufrane D(2015)Dynamics of glucose-induced insulin secretion in normal human islets Am J Physiol Endocrinol Metab 309 E640-E650

[3] Nenquin M(2018)Pancreatic β-cell electrical activity and insulin secretion: Of mice and men Physiol Rev 98 117-214

[4] Henquin JC(2009)Regulation of insulin secretion: a matter of phase control and amplitude modulation Diabetologia 52 739-751

[5] Dufrane D(1999)Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group JAMA 281 2005-2012

[6] Kerr-Conte J(1972)Metabolic characteristics of isolated pancreatic islets in tissue culture Diabetes 21 546-554

[7] Nenquin M(2011)Glucolipotoxicity and beta cells in type 2 diabetes mellitus: target for durable therapy? Diabetes Res Clin Pract 93 S37-S46

[8] Rorsman P(2012)The molecular mechanisms of pancreatic beta-cell glucotoxicity: Recent findings and future research directions Mol Cell Endocrinol 364 1-27

[9] Ashcroft FM(2020)Nutrient-induced metabolic stress, adaptation, detoxification, and toxicity in the pancreatic β-cell Diabetes 69 279-290

[10] Henquin JC(2020)Recent insights into mechanisms of β-cell lipo- and glucolipotoxicity in type 2 diabetes J Mol Biol 432 1514-1534

[1] Henquin JC(2006)Nutrient control of insulin secretion in isolated normal human islets Diabetes 55 3470-3477

[2] Dufrane D(2015)Dynamics of glucose-induced insulin secretion in normal human islets Am J Physiol Endocrinol Metab 309 E640-E650

[3] Nenquin M(2018)Pancreatic β-cell electrical activity and insulin secretion: Of mice and men Physiol Rev 98 117-214

[4] Henquin JC(2009)Regulation of insulin secretion: a matter of phase control and amplitude modulation Diabetologia 52 739-751

[5] Dufrane D(1999)Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group JAMA 281 2005-2012

[6] Kerr-Conte J(1972)Metabolic characteristics of isolated pancreatic islets in tissue culture Diabetes 21 546-554

[7] Nenquin M(2011)Glucolipotoxicity and beta cells in type 2 diabetes mellitus: target for durable therapy? Diabetes Res Clin Pract 93 S37-S46

[8] Rorsman P(2012)The molecular mechanisms of pancreatic beta-cell glucotoxicity: Recent findings and future research directions Mol Cell Endocrinol 364 1-27

[9] Ashcroft FM(2020)Nutrient-induced metabolic stress, adaptation, detoxification, and toxicity in the pancreatic β-cell Diabetes 69 279-290

[10] Henquin JC(2020)Recent insights into mechanisms of β-cell lipo- and glucolipotoxicity in type 2 diabetes J Mol Biol 432 1514-1534