Combined effect of teriparatide and low-intensity pulsed ultrasound for nonunion: A case report

被引：11

作者：

Nozaka K. ^{[1
]}

Shimada Y. ^{[1
]}

Miyakoshi N. ^{[1
]}

Yamada S. ^{[1
]}

Hongo M. ^{[1
]}

Kasukawa Y. ^{[1
]}

Saito H. ^{[1
]}

Kijima H. ^{[1
]}

机构：

[1] Department of Orthopedic Surgery, Akita University, Graduate School of Medicine, Akita 010-8543

来源：

BMC Research Notes | / 7卷 / 1期

关键词：

Bone quality; Low-intensity pulsed ultrasound (LIPUS); Nonunion; Teriparatide;

D O I：

10.1186/1756-0500-7-317

中图分类号：

学科分类号：

摘要：

Background: Low-intensity pulsed ultrasound is a pain-free therapy performed daily at home by the patient and has been shown to promote fracture healing. Teriparatide is a parathyroid hormone preparation that activates osteoblastic bone formation and is also reported to be effective in promoting bony union. Case presentation. We report the case of a 56-year-old Japanese male with a femoral shaft fracture who underwent intramedullary osteosynthesis nailing initially. He had no radiologic or clinical sign of healing 3 months later and low-intensity pulsed ultrasound was initiated at that time. He was reassessed in another 3 months, with evidence of mild bone consolidation but the fracture gap persisted. Subsequent treatment with human parathyroid hormone was initiated in combination with low-intensity pulsed ultrasound. Full fracture healing was present 6 months after beginning the combination low-intensity pulsed ultrasound and teriparatide. It is hypothesized that the potential additive effects of low-intensity pulsed ultrasound and teriparatide therapy ultimately triggered sufficient bone formation to support osseous union. Conclusion: The case reported herein is a femoral shaft atrophic nonunion in which traditional interventions failed. Successful fracture healing was finally achieved with low-intensity pulsed ultrasound and teriparatide therapy. This is the first reported case of diaphyseal nonunion with deterioration of bone quality in long bones resolved with teriparatide and low-intensity pulsed ultrasound. © 2014 Nozaka et al.; licensee BioMed Central Ltd.

引用

共 12 条

[1]

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[2]

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[3]

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