Bicuspid aortic valve aortopathy is characterized by embryonic epithelial to mesenchymal transition and endothelial instability

[1] Sillesen A-S(2021)Prevalence of bicuspid aortic valve and associated aortopathy in Newborns in Copenhagen Denmark JAMA 325 561-567

[2] Vøgg O(2016)Characteristics and long-term outcomes of contemporary patients with bicuspid aortic valves J Thorac Cardiovasc Surg 151 1650-1659.e1

[3] Pihl C(2018)Association of mortality and acute aortic events with ascending aortic aneurysm: a systematic review and meta-analysis JAMA Netw Open 1 182-430

[4] Raja AA(2019)Endothelial/epithelial mesenchymal transition in ascending aortas of patients with bicuspid aortic valve Front Cardiovasc Med 6 422-254

[5] Sundberg K(2011)Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves J Clin Invest 121 244-114

[6] Vedel C(2012)Coordinating tissue interactions: notch signaling in cardiac development and disease Dev Cell 22 102-818

[7] Zingenberg H(2019)The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves J Intern Med 285 811-1437

[8] Jørgensen FS(2022)Large Vessel cell heterogeneity and plasticity: focus in aortic aneurysms Arterioscler Thromb Vasc Biol 42 1429-1108

[9] Vejlstrup N(2009)Biomarkers for epithelial-mesenchymal transitions J Clin Invest 119 1103-1373

[10] Iversen K(2013)Impaired collagen biosynthesis and cross-linking in aorta of patients with bicuspid aortic valve J Am Heart Assoc 2 1365-e124

[1] Sillesen A-S(2021)Prevalence of bicuspid aortic valve and associated aortopathy in Newborns in Copenhagen Denmark JAMA 325 561-567

[2] Vøgg O(2016)Characteristics and long-term outcomes of contemporary patients with bicuspid aortic valves J Thorac Cardiovasc Surg 151 1650-1659.e1

[3] Pihl C(2018)Association of mortality and acute aortic events with ascending aortic aneurysm: a systematic review and meta-analysis JAMA Netw Open 1 182-430

[4] Raja AA(2019)Endothelial/epithelial mesenchymal transition in ascending aortas of patients with bicuspid aortic valve Front Cardiovasc Med 6 422-254

[5] Sundberg K(2011)Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves J Clin Invest 121 244-114

[6] Vedel C(2012)Coordinating tissue interactions: notch signaling in cardiac development and disease Dev Cell 22 102-818

[7] Zingenberg H(2019)The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves J Intern Med 285 811-1437

[8] Jørgensen FS(2022)Large Vessel cell heterogeneity and plasticity: focus in aortic aneurysms Arterioscler Thromb Vasc Biol 42 1429-1108

[9] Vejlstrup N(2009)Biomarkers for epithelial-mesenchymal transitions J Clin Invest 119 1103-1373

[10] Iversen K(2013)Impaired collagen biosynthesis and cross-linking in aorta of patients with bicuspid aortic valve J Am Heart Assoc 2 1365-e124