Transdermal Macromolecular Delivery: Real-Time Visualisation of Iontophoretic and Chemically Enhanced Transport Using Two-Photon Excitation Microscopy

被引：0
作者：
Burrinder S. Grewal
Aarti Naik
William J. Irwin
Gert Gooris
Cees J. de Grauw
Hans G. Gerritsen
Joke A. Bouwstra
机构：
[1] Aston University,Pharmaceutical Sciences Research Institute, Aston Pharmacy School
[2] Leiden University,Leiden/Amsterdam Centre for Drug Research, Gorlaeus Laboratories
[3] Centre Interuniversitaire de Recherche et d'Enseignement,Pharmaceutical Sciences Research Institute, Aston Pharmacy School
[4] Aston University,Debye Institute, Department of Molecular Biophysics
[5] Utrecht University,undefined
来源：
Pharmaceutical Research | 2000年 / 17卷
关键词：
dextran; iontophoresis; stratum corneum; transdermal enhancers; transport pathways; two-photon excitation microscopy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. To investigate the transdermal delivery of a modelmacromolecule by passive and iontophoretic means following pretreatment withC12-penetration enhancers and to visualise transport across humanstratum corneum (SC) in real time.
引用
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页码：788 / 795
页数：7
相关论文
共 79 条
[1]  
Aungst B. J.(1986)Enhancement of Naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides and amides Int. J. Pharm. 33 225-234
[2]  
Rogers N. J.(1992)The influence of alkyl-azones on the ordering of the lamellae in human stratum corneum Int. J. Pharm. 79 141-148
[3]  
Sheffer E.(1985)Vehicle effect on topical drug delivery. III. Effect of Azone on the cutaneous permeation of metronidazole and propylene glycol Int. J. Pharm. 24 19-26
[4]  
Bouwstra J. A.(1995)Mechanism of oleic acid induced skin penetration enhancement J. Contr. Rel. 37 299-306
[5]  
Gooris G. S.(1997)Transdermal iontophoresis of sodium nonivamide acetate. III. Combined effect of pretreatment by penetration enhancers Int. J. Pharm. 149 183-193
[6]  
Brussee J.(1993)Transdermal Iontophoresis of Sotalol and Salicylate; the effect of skin charge and penetration enhancers J. Contr. Rel. 26 109-117
[7]  
Salomons-de Vries M. A.(1992)Iontophoretic delivery of piroxicam across the skin in vitro J. Contr. Rel. 22 57-68
[8]  
Bras W.(1990)Enhancement of the in vitro skin permeability of Azidothymidine (AZT) via iontophoresis and chemical enhancer Pharm. Res. Pharm 7 34-40
[9]  
Wotton P. K.(1993)Solute molecular size and transdermal iontophoresis across excised human skin J. Contr. Rel. 25 177-195
[10]  
MØ llgaard B.(1992)In vitro and in vivo iontophoresis of a tripeptide across nude rat skin J. Contr. Rel. 20 209-218
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