Chronic progressive external ophthalmoplegia.

被引：28
作者：
Lee A.G. [1 ]
Brazis P.W. [1 ]
机构：
[1] Department of Ophthalmology, University of Iowa Hospitals and Clinics, PFP, 200 Hawkins Drive, Iowa City, 52242, IA
来源：
Current Neurology and Neuroscience Reports | 2002年 / 2卷 / 5期
关键词：
Mitochondrial Disease; Extraocular Muscle; Myotonic Dystrophy; Ophthalmoplegia; Adenine Nucleotide Translocator;
D O I：
10.1007/s11910-002-0067-5
中图分类号：
学科分类号：
摘要：
Chronic progressive external ophthalmoplegia (CPEO) is a descriptive term for a heterogenous group of disorders characterized by chronic, progressive, bilateral, and usually symmetric ocular motility deficit and ptosis. Significant pain, proptosis, or pupil involvement are not features of CPEO and should prompt evaluation for alternative etiologies. Mitochondrial DNA mutations are increasingly being recognized as the etiology for CPEO syndromes. Clinicians should recognize the specific syndromes associated with CPEO, characterized by variable systemic, neurologic, or other findings. Treatment is limited, but newer therapies are being investigated.
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页码：413 / 417
页数：4
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