The Apolipoprotein CI A Allele As a Risk Factor for Alzheimer's Disease

被引：0
作者：
S.E. Poduslo
M. Neal
K. Herring
J. Shelly
机构：
[1] Texas Tech University Health Sciences Center,Department of Neurology
来源：
Neurochemical Research | 1998年 / 23卷
关键词：
Alzheimer's disease; apolipoprotein CI; apolipoprotein E;
D O I：
暂无
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学科分类号：
摘要：
The E4 allele for the apolipoprotein E gene has been shown to be a significant risk factor for Alzheimer's disease. The gene is located in a conserved gene cluster on chromosome 19q12-13.2. Downstream from APOE is the gene for apolipoprotein CI. We had previously shown that the presence of a restriction site in the 5′end of APOCI (the A allele) was present at increased frequency in Alzheimer's patients and could also be considered as a risk factor for the disease. We have extended these studies and find that both familial and sporadic cases of Alzheimer's disease have a higher frequency of the APOCI A allele than control spouses. In addition, male patients with the APOCI A allele and/or the APOE4 allele tend to have an earlier age of onset of the disease than female patients.
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页码：361 / 367
页数：6
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