Systemic and coronary levels of CRP, MPO, sCD40L and PlGF in patients with coronary artery disease

被引：31

作者：

Fong S.W. ^{[1
]}

Few L.L. ^{[1
]}

See Too W.C. ^{[1
]}

Khoo B.Y. ^{[2
]}

Nik Ibrahim N.N.I. ^{[3
]}

Yahaya S.A. ^{[4
]}

Yusof Z. ^{[3
]}

Mohd Ali R. ^{[4
]}

Abdul Rahman A.R. ^{[5
]}

Yvonne-Tee G.B. ^{[1
]}

机构：

[1] School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan

[2] Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Penang

[3] School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan

[4] National Heart Institute, 50400, Kuala Lumpur

[5] Cyberjaya University, College of Medical Sciences, Cyberjaya, 63000, Selangor

来源：

BMC Research Notes | / 8卷 / 1期

基金：

美国国家科学基金会;

关键词：

Biomarker; Coronary artery disease; Coronary circulation; Systemic circulation;

D O I：

10.1186/s13104-015-1677-8

中图分类号：

学科分类号：

摘要：

Background: Biomarkers play a pivotal role in the diagnosis and management of patients with acute coronary syndrome. This study aimed to investigate the differences in level of several biomarkers, i.e. C-reactive protein, myeloperoxidase, soluble CD40 ligand and placental growth factor, between acute coronary syndrome and chronic stable angina patients. The relationship between these biomarkers in the coronary circulation and systemic circulation was also investigated. Methods: A total of 79 patients were recruited in this study. The coronary blood was sampled from occluded coronary artery, while the peripheral venous blood was withdrawn from antecubital fossa. The serum concentrations of C-reactive protein, soluble CD40 ligand and placental growth factor and plasma concentration of myeloperoxidase were measured using ELISA method. Results: The systemic level of the markers measured in the peripheral venous blood was significantly increased in acute coronary syndrome compared to chronic stable angina patients. The concentrations of the C-reactive protein, myeloperoxidase and soluble CD40 ligand taken from peripheral vein were closely similar to the concentration found in coronary blood of ACS patients. The level of placental growth factor was significantly higher in coronary circulation than its systemic level. Conclusion: The concentration of these C-reactive protein, myeloperoxidase, soluble CD40 ligand and placental growth factor were significantly increased in acute coronary syndrome patients. The concentration of the markers measured in the systemic circulation directly reflected those in the local coronary circulation. Thus, these markers have potential to become a useful tool in predicting plaque vulnerability in the future. © 2015 Fong et al.

引用

共 26 条

[1]

Apple F.S., Wu A.H., Mair J., Ravkilde J., Panteghini M., Tate J., Pagani F., Christenson R.H., Mockel M., Danne O., Jaffe A.S., Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome, Clin Chem, 51, pp. 810-824, (2005)

[2]

Fu X., Kassim S.Y., Parks W.C., Heinecke J.W., Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7). A mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidase, J Biol Chem, 276, pp. 41279-41287, (2001)

[3]

Shabani F., McNeil J., Tippett L., The oxidative inactivation of tissue inhibitor of metalloproteinase-1 (TIMP-1) by hypochlorous acid (HOCI) is suppressed by anti-rheumatic drugs, Free Radic Res, 28, pp. 115-123, (1998)

[4]

Andre P., Nannizzi-Alaimo L., Prasad S.K., Phillips D.R., Platelet-derived CD40L: The switch-hitting player of cardiovascular disease, Circulation, 106, pp. 896-899, (2002)

[5]

Schonbeck U., Libby P., CD40 signaling and plaque instability, Circ Res, 89, pp. 1092-1103, (2001)

[6]

Maglione D., Guerriero V., Viglietto G., Delli-Bovi P., Persico M.G., Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor, Proc Natl Acad Sci, 88, pp. 9267-9271, (1991)

[7]

Iyer S., Acharya K.R., Role of placenta growth factor in cardiovascular health, Trends Cardiovasc Med, 12, pp. 128-134, (2002)

[8]

Heeschen C., Dimmeler S., Hamm C.W., Van Den Brand M.J., Boersma E., Zeiher A.M., Simoons M.L., Soluble CD40 ligand in acute coronary syndromes, N Engl J Med, 348, pp. 1104-1111, (2003)

[9]

Heeschen C., Dimmeler S., Fichtlscherer S., Hamm C.W., Berger J., Simoons M.L., Zeiher A.M., Prognostic value of placental growth factor in patients with acute chest pain, JAMA, 291, pp. 435-441, (2004)

[10]

Ndrepepa G., Braun S., Mehilli J., Von Beckerath N., Schomig A., Kastrati A., Myeloperoxidase level in patients with stable coronary artery disease and acute coronary syndromes, Eur J Clin Invest, 38, pp. 90-96, (2008)

← 1 2 3 →