Treating headaches with botulinum toxin

被引：0
作者：
Marco Aguggia
机构：
[1] Neurological Department,
来源：
Neurological Sciences | 2008年 / 29卷
关键词：
Botulinum toxin type A; Headache; Pain; Prophylaxis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Botulinum toxin type A (BT-a) has been shown to effectively treat several types of neurological disorders. For over 15 years it has been used clinically also for the prophylaxis and treatment of various types of primary headache disorders. Although BT-a efficacy has not been proven in tension-type headache, its use in migraine continues to cause controversy. There is adequate data to support the hypothesis, beside its well known effect on acetylcholine release, of an additional antinociceptive effect related to a block in the local release of nociceptive neuropeptides.
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页码：137 / 139
页数：2
相关论文
共 46 条
[1]  
Collins A.(2006)Botulinum toxin injection for congenital muscular torticollis presenting in children and adults Neurology 76 1083-1085
[2]  
Jankovic J.(2003)Botulinum toxin injections for headache Headache 43 682-685
[3]  
Ewans R.W.(2002)The use of botulinum toxin type A in headache treatment Curr Treat Options Neurol 4 365-373
[4]  
Blumenfeld A.(1981)The origin, structure and pharmacological activity of botulinum toxin Pharmacol Rev 33 155-188
[5]  
Mathew N.T.(2001)Pharmacology and immunology of botulinum toxin serotypes J Neurol 248 3-10
[6]  
Kaup A.O.(2000)Capsaicinstimulated release of substance P from cultured dorsal root ganglion neurons: involvement of two distinct mechanisms Biochem Pharmacol 59 1403-1406
[7]  
Simpson L.L.(2004)Regulation of calcitonin gene-related peptide secretion from trigeminal nerve cells by botulinum toxin type A: implications for migraine therapy Headache 44 35-43
[8]  
Aoki K.R.(2006)Botulinum toxin therapy of migraine and tension-type headache Eur J Neurol 13 51-54
[9]  
Purkiss J.(2003)Botulinum toxin type A as an effective prophylactic treatment in primary headache disorders Headache 43 853-860
[10]  
Welch M.K.A.(2007)A double-blind, randomized, placebo-controlled comparison of botulinum toxin type A injection sites and doses in the prevention of episodic migraine Pain Med 8 478-485
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