Protective effects of vitamin E against CCl4-induced hepatotoxicity in rabbits

被引：0

作者：

K. Pawłowska-Góral

M. Wardas

P. Wardas

A. Rzepecka-Stojko

机构：

[1] Medical University of Silesia,Department of Food and Nutrition

[2] E. N. T. Clinic of Medical University of Silesia,undefined

来源：

Chemical Papers | 2007年 / 61卷

关键词：

antioxidant enzymes; glutathione; total antioxidant status; malonic dialdehyde; vitamin E;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The influence of CCl4 on the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), the value of the total antioxidant status (TAS), and the concentration of malonic dialdehyde (MDA) and glutathione (GSH) was monitored in plasma or whole blood of rabbits. The administration of CCl4 caused the increase of the SOD activity to approximately 150 % and the decrease in the activity of GPx and GR by about 50 %. These changes were accompanied with the increase in TAS value and MDA concentration and the decrease of GSH concentration. The effect of CCl4 was suppressed by the previous 7 days lasting or simultaneous administration of vitamin E. Oxidative stress caused by CCl4 was accompanied by the development of reactive oxygen forms, especially superoxide radical anion.

引用

页码：6 / 10

页数：4

共 50 条

[21] Antioxidant and Pulmonary Protective Potential of Fraxinus xanthoxyloides Bark Extract against CCl4-Induced Toxicity in Rats
Younis, Tahira
Jabeen, Faiza
Hussain, Ali
Rasool, Bilal
Raza Ishaq, Ali
Nawaz, Atif
El-Nashar, Heba A. S.
El-Shazly, Mohamed
CHEMISTRY & BIODIVERSITY, 2023, 20 (03)
[22] Protective effects of vitamins C and E against hepatotoxicity induced by methyl parathion in rats
Uzunhisarcikli, Meltem
Kalender, Yusuf
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2011, 74 (07) : 2112 - 2118
[23] Attenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis
Wali, Adil Farooq
Ali, Shafat
Rashid, Summya
Alsaffar, Rana M.
Arafah, Azher
Qamar, Wajhul
Ahmad, Ajaz
Paray, Bilal Ahmad
Ahmad, Sheikh Bilal
Alsuwayni, Bashayr M.
Rehman, Muneeb U.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE, 2021, 33 (08)
[24] Modulatory Effect of Methanol Extract of Piper guineense in CCl4-Induced Hepatotoxicity in Male Rats
Oyinloye, Babatunji Emmanuel
Osunsanmi, Foluso Oluwagbemiga
Ajiboye, Basiru Olaitan
Ojo, Oluwafemi Adeleke
Kappo, Abidemi Paul
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2017, 14 (09)
[25] Protective Mechanisms of Moringa oleifera against CCl4-Induced Oxidative Stress in Precision-Cut Liver Slices
Sreelatha, Sarangapani
Padma, P. Ragunathan
FORSCHENDE KOMPLEMENTARMEDIZIN, 2010, 17 (04): : 189 - 194
[26] Protective Effects of Water Extract of Clam on Normal and CCl4-Induced Damage in Primary Cultured Rat Hepatocytes
Chi, H. M.
Chou, S. T.
Lin, S. C.
Su, Z. Y.
Sheen, Lee-Yan
AMERICAN JOURNAL OF CHINESE MEDICINE, 2010, 38 (06): : 1193 - 1205
[27] Protective effects of vitamin E against atrazine-induced genotoxicity in rats
Singh, Mohan
Kaur, Pushpindar
Sandhir, Rajat
Kiran, Ravi
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2008, 654 (02) : 145 - 149
[28] Protective Effects of Coadministration of the Vitamin E and Omega-3 on Doxorubicin-Induced Hepatotoxicity in Mice
Lotfi, Amirhosain
Rafie, Siamak Mashhady
Hesaraki, Saeed
Amini, Kumarss
INTERNATIONAL JOURNAL OF CANCER MANAGEMENT, 2022, 15 (10)
[29] Effects of phoxim-induced hepatotoxicity on SD rats and the protection of vitamin E
Jing Zhang
Wentao Song
Yuecheng Sun
Anshan Shan
Environmental Science and Pollution Research, 2017, 24 : 24916 - 24927
[30] Effects of phoxim-induced hepatotoxicity on SD rats and the protection of vitamin E
Zhang, Jing
Song, Wentao
Sun, Yuecheng
Shan, Anshan
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2017, 24 (32) : 24916 - 24927

← 1 2 3 4 5 →