TGF-β signaling in esophageal squamous cell carcinoma

被引：1

作者：

Fukuchi M. ^{[1
]}

Kato H. ^{[1
]}

Kuwano H. ^{[1
]}

机构：

[1] Dept. of General Surgical Science, Gunma University, Graduate School of Medicine, Gunma 371-8511, 3-39-22 Showa-machi, Maebashi

来源：

Esophagus | 2005年 / 2卷 / 1期

关键词：

Esophageal squamous cell carcinoma; TGF-β;

D O I：

10.1007/s10388-004-0033-1

中图分类号：

学科分类号：

摘要：

Transforming growth factor-β (TGF-β) regulates cell growth inhibition, and perturbations of TGF-β signaling contribute to tumor development. The effects of TGF-β growth inhibition are mediated by TGF-β-specific receptors, signal transducer Smad proteins, and various transcription factors. Although mutation of these genes is rare in esophageal cancer, alteration of the expression of these mediators correlates with tumor progression and poor prognosis. Consequently, esophageal cancer may have difficulty in the transmission of TGF-β signaling and show loss of the growth inhibitory responses to TGF-β. As well, the mechanisms of expression of TGF-β signaling mediators appear to be regulated by ubiquitin-dependent degradation. In summary, modulation of the expression of TGF-β signaling mediators is involved in the progression of esophageal cancer. © Japan Esophageal Society and Springer-Verlag 2005.

引用

页码：15 / 19

页数：4

共 45 条

[1]

Sugimachi K., Watanabe M., Sadanaga N., Ikebe M., Kitamura K., Mori M., Et al., Recent advances in the diagnosis and surgical treatment of patients with carcinoma of the esophagus, J Am Coll Surg, 178, pp. 363-368, (1994)

[2]

Kodama M., Kakegawa T., Treatment of superficial cancer of the esophagus: A summary of responses to a questionnaire on superficial cancer of the esophagus in Japan, Surgery, 123, pp. 432-439, (1998)

[3]

Kuwano H., Masuda N., Kato H., Sugimachi K., The subepithelial extension of esophageal carcinoma for determining the resection margin during esophagectomy: A serial histopathologic investigation, Surgery, 131, (2002)

[4]

Shimada Y., Imamura M., Shibagaki I., Tanaka H., Miyahara T., Kato M., Et al., Genetic alterations in patients with esophageal cancer with short- and long-term survival rates after curative esophagectomy, Ann Surg, 226, pp. 162-168, (1997)

[5]

Shiozaki H., Doki Y., Kawanishi K., Shamma A., Yano M., Inoue M., Et al., Clinical application of malignancy potential grading as a prognostic factor of human esophageal cancers, Surgery, 127, pp. 552-561, (2000)

[6]

White R.L., Tumor suppressing pathways, Cell, 92, pp. 591-592, (1998)

[7]

Markowitz S.D., Roberts A.B., Tumor suppressor activity of the TGF-β pathway in human cancers, Cytokine Growth Factor Rev, 7, pp. 93-102, (1996)

[8]

Markowitz S., Wang J., Myeroff L., Parsons R., Sun L., Lutterbaugh J., Et al., Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability, Science, 268, pp. 1336-1338, (1995)

[9]

Hahn S.A., Schutte M., Hoque A.T., Moskaluk C.A., DaCosta L.T., Rozenblum E., Et al., DPC4, a candidate tumor suppressor gene at chromosome 18q21.1, Science, 271, pp. 350-353, (1996)

[10]

Miyaki M., Iijima T., Konishi M., Sakai K., Ishii A., Yasuno M., Et al., Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis, Oncogene, 18, pp. 3098-3103, (1999)

← 1 2 3 4 5 →