Awakening dormant haematopoietic stem cells

被引：0
作者：
Andreas Trumpp
Marieke Essers
Anne Wilson
机构：
[1] Andreas Trumpp and Marieke Essers are at the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM),and the Division of Stem Cells and Cancer
[2] German Cancer Research Center (DKFZ),undefined
[3] Im Neuenheimer Feld 280,undefined
[4] D-69,undefined
[5] 120 Heidelberg,undefined
[6] Germany.,undefined
[7] Anne Wilson is at the Ludwig Institute for Cancer Research Ltd.,undefined
[8] Lausanne Branch,undefined
[9] University of Lausanne,undefined
[10] 1066 Epalinges,undefined
[11] Switzerland.,undefined
来源：
Nature Reviews Immunology | 2010年 / 10卷
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摘要：
Haematopoietic stem cells (HSCs) can reside as dormant cells in endosteal niches in the bone marrow, where they are resistant to certain types of chemotherapy. In this article, the authors suggest that by first awakening dormant HSCs to become actively self-renewing cells, this resistance to chemotherapy could be overcome.
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页码：201 / 209
页数：8
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