Nasal Delivery of Insulin Using Novel Chitosan Based Formulations: A Comparative Study in Two Animal Models Between Simple Chitosan Formulations and Chitosan Nanoparticles

被引:0
|
作者
A. M. Dyer
M. Hinchcliffe
P. Watts
J. Castile
I. Jabbal-Gill
R. Nankervis
A. Smith
L. Illum
机构
[1] Clinical Research Centre Ltd.,West Pharmaceutical Services, Drug Delivery &
来源
Pharmaceutical Research | 2002年 / 19卷
关键词
chitosan; nanoparticles; complex; nasal delivery; insulin;
D O I
暂无
中图分类号
学科分类号
摘要
Purpose. To investigate whether the widely accepted advantages associated with the use of chitosan as a nasal drug delivery system, might be further improved by application of chitosan formulated as nanoparticles.
引用
收藏
页码:998 / 1008
页数:10
相关论文
共 50 条
  • [1] Nasal delivery of insulin using novel chitosan based formulations: A comparative study in two animal models between simple chitosan formulations and chitosan nanoparticles
    Dyer, AM
    Hinchcliffe, M
    Watts, P
    Castile, J
    Jabbal-Gill, I
    Nankervis, R
    Smith, A
    Illum, L
    PHARMACEUTICAL RESEARCH, 2002, 19 (07) : 998 - 1008
  • [2] Enhanced siRNA delivery with novel smart chitosan-based formulations
    Kundapura, Srujan
    Craske, Dominic
    Hickman, Graham
    Braim, Shwana
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2025, 114 (04)
  • [3] Chitosan-based formulations for delivery of DNA and siRNA
    Mao, Shirui
    Sun, Wei
    Kissel, Thomas
    ADVANCED DRUG DELIVERY REVIEWS, 2010, 62 (01) : 12 - 27
  • [4] Nasal delivery of insulin using chitosan microspheres
    Varshosaz, J
    Sadrai, H
    Alinagari, R
    JOURNAL OF MICROENCAPSULATION, 2004, 21 (07) : 761 - 774
  • [5] Prospective applications of chitosan and chitosan-based nanoparticles formulations in sustainable agricultural practices
    Karamchandani, Bhoomika M.
    Dalvi, Sunil G.
    Bagayatkar, Mahima
    Banat, Ibrahim M.
    Satpute, Surekha K.
    BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, 2024, 58
  • [6] Clearance characteristics of chitosan based formulations in the sheep nasal cavity
    Soane, RJ
    Hinchcliffe, M
    Davis, SS
    Illum, L
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 217 (1-2) : 183 - 191
  • [7] Microencapsulated chitosan nanoparticles for pulmonary protein delivery: In vivo evaluation of insulin-loaded formulations
    Al-Qadi, S.
    Grenha, A.
    Carrion-Recio, D.
    Seijo, B.
    Remunan-Lopez, C.
    JOURNAL OF CONTROLLED RELEASE, 2012, 157 (03) : 383 - 390
  • [8] Nasal delivery of insulin using bioadhesive chitosan gels
    Varshosaz, J
    Sadrai, H
    Heidari, A
    DRUG DELIVERY, 2006, 13 (01) : 31 - 38
  • [9] Enhancement of nasal absorption of insulin using chitosan nanoparticles
    Fernández-Urrusuno, R
    Calvo, P
    Remuñán-López, C
    Vila-Jato, JL
    Alonso, MJ
    PHARMACEUTICAL RESEARCH, 1999, 16 (10) : 1576 - 1581
  • [10] Enhancement of Nasal Absorption of Insulin Using Chitosan Nanoparticles
    Rocío Fernández-Urrusuno
    Pilar Calvo
    Carmen Remuñán-López
    Jose Luis Vila-Jato
    María José Alonso
    Pharmaceutical Research, 1999, 16 : 1576 - 1581