Combined praziquantel and albendazole chemoprophylaxis in experimental hydatidosis

被引：27

作者：

Casado N. ^{[1
]}

Urrea-París M. ^{[1
]}

Moreno M. ^{[1
]}

Rodríguez-Caabeiro F. ^{[1
]}

机构：

[1] Parasitology Laboratory, Faculty of Pharmacy, University of Alcalá, Alcala de Henares, 28871, Madrid

来源：

Parasitology Research | 2001年 / 87卷 / 9期

关键词：

Electron Microscopy; Transmission Electron Microscopy; Treatment Period; Severe Damage; Treated Mouse;

D O I：

10.1007/s004360100443

中图分类号：

学科分类号：

摘要：

The results of the chemoprophylaxis of experimental hydatidosis with a combination of praziquantel and albendazole are presented. In vivo studies were performed on NMRI mice injected with protoscolices of Echinococcus granulosus. The treatment was the same as that previously used by us, but reducing the treatment period to only 1 month. Four months after injection, the mice were killed and autopsied. Developed hydatid cysts were counted, weighed and processed for observation by transmission electron microscopy. The efficacy of the present treatment was 97.7% and 97.15%, in number and weight of the cysts respectively, only slightly lower than that obtained by us after 4 months of treatment. Moreover, the few cysts that had developed in the treated mice showed severe damage to their ultrastructure.

引用

页码：787 / 789

页数：2

共 9 条

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[2]

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[8]

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[9]

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