Disruption of Circadian Rhythms by Light During Day and Night

被引：43
作者：
Figueiro M.G. [1 ]
机构：
[1] Lighting Research Center, Rensselaer Polytechnic Institute, Troy, 12180, NY
来源：
Current Sleep Medicine Reports | 2017年 / 3卷 / 2期
关键词：
Cancer in shift workers; Circadian disruption; Circadian phototransduction; Circadian rhythms; Daytime light; Light at night;
D O I：
10.1007/s40675-017-0069-0
中图分类号：
学科分类号：
摘要：
Purpose of Review: This study aims to discuss possible reasons why research to date has not forged direct links between light at night, acute melatonin suppression or circadian disruption, and risks for disease. Recent Findings: Data suggest that irregular light–dark patterns or light exposures at the wrong circadian time can lead to circadian disruption and disease risks. However, there remains an urgent need to (1) specify light stimulus in terms of circadian rather than visual response; (2) when translating research from animals to humans, consider species-specific spectral and absolute sensitivities to light; (3) relate the characteristics of photometric measurement of light at night to the operational characteristics of the circadian system; and (4) examine how humans may be experiencing too little daytime light, not just too much light at night. Summary: To understand the health effects light-induced circadian disruption, we need to measure and control light stimulus during the day and at night. © 2017, Springer International Publishing AG.
引用
收藏
页码：76 / 84
页数：8
相关论文
共 87 条
  • [1] Turek F.W., Circadian clocks: not your grandfather’s clock, Science, 354, 6315, pp. 992-993, (2016)
  • [2] Stephan F.K., Zucker I., Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalmaic lesions, Proc Natl Acad Sci U S A, 69, pp. 1583-1586, (1972)
  • [3] Klein D.C., Moore R.Y., Reppert S.M., Suprachiasmatic nucleus: the mind’s clock, (1991)
  • [4] Ebihara S., Tsuji K., Entrainment of the circadian activity rhythm to the light cycle: effective light intensity for a Zeitgeber in the retinal degenerate C3H mouse and the normal C57BL mouse, Physiol Behav, 24, 3, pp. 523-527, (1980)
  • [5] Foster R., Provencio I., Hudson D., Et al., Circadian photoreception in the retinally degenerate mouse (rd/rd), J Comp Physiol A., 169, 1, pp. 39-50, (1991)
  • [6] Berson D., Dunn F., Takao M., Phototransduction by retinal ganglion cells that set the circadian clock, Science, 295, 5557, pp. 1070-1073, (2002)
  • [7] Provencio I., Rodriguez I.R., Jiang G., Hayes W.P., Moreira E.F., Rollag M.D., A novel human opsin in the inner retina, J Neurosci, 20, 2, pp. 600-605, (2000)
  • [8] Hattar S., Lucas R.J., Mrosovsky N., Thompson S.H., Douglas R.H., Hankins M.W., Et al., Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice, Nature, 424, pp. 75-81, (2003)
  • [9] Ruby N., Brennan T., Xie X., Role of melanopsin in circadian responses to light, Science, 298, pp. 2211-2213, (2002)
  • [10] Panda S., Provencio I., Tu D.C., Pires S.S., Rollag M.D., Castrucci A.M., Et al., Melanopsin is required for non-image-forming photic responses in blind mice, Science, 301, 5632, pp. 525-527, (2003)
123456789