1,3,4,6-tetracarbonyl systems. Part 8. Synthesis and antimicrobial activity of 2(5)-halogenated derivatives of 1,3,4,6-tetracarbonyl compounds

被引：0

作者：

Kozminykh E.N. ^{[1
]}

Goncharov V.I. ^{[2
]}

Kozminykh V.O. ^{[3
]}

机构：

[1] Moscow State University of Technology and Management (Perm Division), Perm

[2] Stavropol State Medical Academy, Stavropol

[3] Perm State Pedagogical University, Perm

来源：

Pharmaceutical Chemistry Journal | 2008年 / 42卷 / 9期

关键词：

Minimum Inhibit Concentration; Cefepime; Nitrofural; Dienoic Acid; Bacteriostatic Activity;

D O I：

10.1007/s11094-009-0172-8

中图分类号：

学科分类号：

摘要：

A series of 1,6-disubstituted 2,5-dibromohexan-1,3,4,6-tetraones and 2,2,5,5-tetrahalogenohexan-1,3,4,6-tetraones have been obtained by the treatment of 1,6-disubstituted hexane-1,3,4,6-tetraones with bromine and chlorine. Bromination of (4Z)-6-aryl-3,4-dihydroxy-6-oxohexa-2,4-dienamides led to (2Z,4E)-2-aminocarbonyl-6-aryl-5-bromo-3,4-dihydroxy-6-oxohexa-2,4-dienoates and 6-aryl-2,5-dibromo-3,4,6-trioxohexanamides in preparative yield. The proposed structures of the reaction products were confirmed by IR, UV, 1H and 13C NMR, and mass spectrometry. The bacteriostatic activity and acute toxicity of the synthesized compounds have been studied. © 2008 Springer Science+Business Media, Inc.

引用

页码：513 / 519

页数：6