Synthesis and Antidepressant Properties of 3-Methyl-7-(1,1-Dioxothietan-3-YL)-8-Cyclohexylamino-1-Ethyl-1H-Purine-2,6(3H,7H)-Dione

被引：0

作者：

F. A. Khaliullin

Yu. V. Shabalina

G. G. Davlyatova

L. A. Valeeva

机构：

[1] Bashkir State Medical University,

[2] Ministry of Health of the RF,undefined

[3] Ufa,undefined

来源：

Pharmaceutical Chemistry Journal | 2018年 / 51卷

关键词：

xanthines; thietanes; synthesis; antidepressant activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

3-Methyl-7-(1,1-dioxothietan-3-yl)-8-cyclohexylamino-1-ethyl-1H-purine-2,6(3H,7H)-dione was synthesized via the reaction of 8-bromo-3-methyl-7-(1,1-dioxothietan-3-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione and cyclohexylamine and exhibited antidepressant activity that was most pronounced at a dose of 1.6 mg/kg.

引用

页码：1049 / 1052

页数：3

共 14 条

[1]

Katsushima T(1990)undefined J. Med. Chem. 33 1906-1910

[2]

Nieves L(1991)undefined Khim. Geterotsikl. Soedin. 4 516-518

[3]

Wells J(2010)undefined Zh. Org. Khim. 46 698-701

[4]

Khaliullin FA(1989)undefined Zh. Vyssh. Nervn. Deyat. im. I. P. Pavlova 5 958-964

[5]

Kataev VA(2009)undefined Med. Vestn. Bashkortostana 4 186-188

[6]

Strokin YV(undefined)undefined undefined undefined undefined-undefined

[7]

Khaliullin FA(undefined)undefined undefined undefined undefined-undefined

[8]

Shabalina YV(undefined)undefined undefined undefined undefined-undefined

[9]

Sharafutdinov RM(undefined)undefined undefined undefined undefined-undefined

[10]

Shchetinin EV(undefined)undefined undefined undefined undefined-undefined

← 1 2 →