It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation

被引：0
|
作者：
Hannah J. Wiedner
Jimena Giudice
机构：
[1] University of North Carolina at Chapel Hill,Department of Cell Biology and Physiology
[2] University of North Carolina at Chapel Hill,Curriculum in Genetics and Molecular Biology
[3] University of North Carolina at Chapel Hill,McAllister Heart Institute, School of Medicine
来源：
Nature Structural & Molecular Biology | 2021年 / 28卷
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摘要：
Biomolecular condensates that form via phase separation are increasingly regarded as coordinators of cellular reactions that regulate a wide variety of biological phenomena. Mounting evidence suggests that multiple steps of the RNA life cycle are organized within RNA-binding protein-rich condensates. In this Review, we discuss recent insights into the influence of phase separation on RNA biology, which has implications for basic cell biology, the pathogenesis of human diseases and the development of novel therapies.
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页码：465 / 473
页数：8
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