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Stem cells and their niche: a matter of fate
被引：0
作者：
O. Naveiras
G. Q. Daley
机构：
[1] Harvard Medical School,Graduate Program of Biological and Biomedical Sciences, and Div. of Hematology/Oncology
[2] Children’s Hospital,Division of Hematology/Oncology, and Department of Biological Chemistry and Molecular Pharmacology
[3] Children’s Hospital,undefined
[4] Harvard Medical School,undefined
来源：
Cellular and Molecular Life Sciences CMLS
|
2006年
/
63卷
关键词：
Embryonic stem cell;
somatic stem cell;
niche;
asymmetric division;
self-renewal;
differentiation;
regenerative medicine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Embryonic stem cells provide an in vitro model for developmental biologists to study cell fate decisions during ontogenesis, while somatic stem cells allow physiologists to understand tissue homeostasis in the adult. The behavior of stem cells is dependent on an intimate relationship with a supportive niche. This brief review highlights some of the most important recent trends in stem cell biology, focusing in particular on the supportive microenvironments for both embryonic and adult stem cells. Known intrinsic and extrinsic molecular players from the best-characterized stem cell types are summarized, illuminating a number of shared environmental cues among tissues originating from all three embryonic germ layers.
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页码：760 / 766
页数：6
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