Cell-associated HIV RNA: a dynamic biomarker of viral persistence

被引：0
作者：
Alexander O Pasternak
Vladimir V Lukashov
Ben Berkhout
机构：
[1] University of Amsterdam,Department of Medical Microbiology, Laboratory of Experimental Virology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center
来源：
Retrovirology | / 10卷
关键词：
Cell-associated HIV RNA; Virological biomarker; HIV-1 persistence; HIV-1 reservoir; Antiretroviral therapy; HIV cure;
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摘要：
In most HIV-infected individuals adherent to modern antiretroviral therapy (ART), plasma viremia stays undetectable by clinical assays and therefore, additional virological markers for monitoring and predicting therapy responses and for measuring the degree of HIV persistence in patients on ART should be identified. For the above purposes, quantitation of cell-associated HIV biomarkers could provide a useful alternative to measurements of viral RNA in plasma. This review concentrates on cell-associated (CA) HIV RNA with the emphasis on its use as a virological biomarker. We discuss the significance of CA HIV RNA as a prognostic marker of disease progression in untreated patients and as an indicator of residual virus replication and the size of the dynamic viral reservoir in ART-treated patients. Potential value of this biomarker for monitoring the response to ART and to novel HIV eradication therapies is highlighted.
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