Cytotoxic diarylheptanoid induces cell cycle arrest and apoptosis via increasing ATF3 and stabilizing p53 in SH-SY5Y cells

被引:0
作者
Ze Tian
Ning An
Bin Zhou
Peigen Xiao
Isaac S. Kohane
Erxi Wu
机构
[1] Children’s Hospital Boston,Informatics Program, MIT Division of Health Sciences and Technology
[2] Harvard Medical School,Division of Health Sciences and Technology
[3] Harvard University and Massachusetts Institute of Technology,Institute of Medicinal Plant Development
[4] Chinese Academy of Medical Sciences and Peking Union Medical College,Department of Cardiology, Children’s Hospital Boston
[5] Harvard Medical School,undefined
来源
Cancer Chemotherapy and Pharmacology | 2009年 / 63卷
关键词
Diarylheptanoid; Cell cycle arrest; Apoptosis; p53; ATF3;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1131 / 1139
页数:8
相关论文
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  • [1] An N(2008)Diarylheptanoids from the rhizomes of Fitoterapia 79 27-31
  • [2] Zou ZM(2007) and their anticancer activity Mol Pharmacol 72 29-39
  • [3] Tian Z(2007)Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways Clin Transl Oncol 9 478-483
  • [4] Luo XZ(1999)Molecular biology of neuroblastoma Proc Natl Acad Sci USA 96 13777-13782
  • [5] Yang SL(2001)Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage Nat Genet 27 48-54
  • [6] Xu LZ(2003)Transcriptional regulation and function during the human cell cycle Carcinogenesis 24 1515-1524
  • [7] Aoki H(2002)Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation Oncogene 21 7488-7496
  • [8] Takada Y(1996)ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth Am J Pathol 148 1381-1385
  • [9] Kondo S(2005)The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization Cancer Lett 228 133-141
  • [10] Sawaya R(2001)Targeting programmed cell death pathways with experimental therapeutics: opportunities in high-risk neuroblastoma Gene 273 1-11