Impaired response of granulocyte-committed progenitor cells to stem cell factor and granulocyte colony-stimulating factor in human cyclic neutropenia

被引：0

作者：

A. Takami

S. Nakao

S. Koizumi

T. Matsuda

机构：

[1] Department of Medicine,

[2] Kurobe City Hospital,undefined

[3] 1108-1 Mikkaichi,undefined

[4] Kurobe,undefined

[5] Toyama 938,undefined

[6] Japan Tel.: 0081-765-54-2211,undefined

[7] Fax: 0081-765-54-1022,undefined

[8] Third Department of Medicine,undefined

[9] Kanazawa University School of Medicine,undefined

[10] Kanazawa,undefined

[11] Ishikawa,undefined

[12] Japan,undefined

[13] Department of Pediatrics,undefined

[14] Kanazawa University School of Medicine,undefined

[15] Kanazawa,undefined

[16] Ishikawa,undefined

[17] Japan,undefined

来源：

Annals of Hematology | 1999年 / 78卷

关键词：

Key words Cyclic neutropenia; Stem cell factor; Granulocyte colony-stimulating factor;

D O I：

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中图分类号：

学科分类号：

摘要：

Although cyclic neutropenia (CN) has been the subject of extensive studies due to its striking clinical picture, the abnormality of hematopoietic progenitor cells in patients with CN has been poorly defined. We studied the sensitivity of progenitor cells of a CN patient to colony-stimulating factors (CSF) including G-CSF, interleukin-3 (IL-3), and stem cell factor (SCF). Peripheral blood progenitor cells of the patient required a significantly higher dose of G-CSF to give rise to colonies than those of normal controls. While the presence of SCF enhanced the number of G-CSF-induced colonies regardless of the concentration of G-CSF in normal controls, this synergistic effect of SCF was limited to the high concentration of G-CSF in the patient, indicating that the abnormality in hematopoiesis in CN involved more immature progenitor cells responsive to SCF.

引用

页码：197 / 199

页数：2