Treatment of a patient with a nodal peripheral T-cell lymphoma (Angioimmunoblastic T-cell lymphoma) with a human monoclonal antibody against the CD4 antigen (HuMax-CD4)

被引：0

作者：

H. Hagberg

M. Pettersson

T. Bjerner

G. Enblad

机构：

[1] Akademiska sjukhuset,Division of Pharmacokinetics and Drug Therapy

[2] Akademiska sjukhuset,Department of Radiology

[3] Akademiska sjukhuset,Department of Oncology

来源：

Medical Oncology | 2005年 / 22卷

关键词：

Peripheral T-cell lymphoma; angioimmunoblastic T-cell lymphoma; HuMax-CD4;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A patient with a CD4+ refractory peripheral T-cell lymphoma (PTL), subtype angioimmunoblastic T-cell lymphoma (AILD), was treated with a human monoclonal anti-CD4 antibody (HuMax-CD4) iv once weekly for 10 wk. Early during treatment all palpable enlarged lymph nodes disappeared. A decline of normal CD4+ T-cells in the blood mirrored the treatment effect. Shortly after stopping treatment the patient relapsed with new enlarged lymph nodes. This time no antitumor effect was seen when HuMax-CD4 treatment was reinstituted. No severe side effects were observed during the antibody treatment. This case report is the first describing that HuMax-CD4 has antilymphoma activity in PTL and is an interesting drug to study further in patients with CD4+ PTL.

引用

页码：191 / 194

页数：3

共 10 条

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