Evaluation of the kappa-opioid receptor-selective tracer [11C]GR103545 in awake rhesus macaques

[1] Mansour A(1988)Anatomy of CNS opioid receptors Trends Neurosci 11 308-314

[2] Khachaturian H(2008)Imaging of opioid receptors in the central nervous system Brain 131 1171-1196

[3] Lewis ME(1995)Kappa opioid inhibition of morphine and cocaine self-administration in rats Brain Res 681 147-152

[4] Akil H(2009)Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuse J Nat Prod 72 581-587

[5] Watson SJ(2001)Mu-, delta- and kappa-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer’s disease patients Brain Res 893 121-134

[6] Henriksen G(1999)Region-specific changes in prodynorphin mRNA and ir-dynorphin A levels after kindled seizures J Mol Neurosci 13 69-75

[7] Willoch F(1993)A potent new class of kappa-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines J Med Chem 36 2075-2083

[8] Glick SD(1999)[11C]-methyl 4-[(3, 4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl)-methyl]-1- piperazinecarboxylate ([11C]GR89696): synthesis and in vivo binding to kappa opiate receptors Nucl Med Biol 26 737-741

[9] Maisonneuve IM(2002)[(11)C]-GR89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers Nucl Med Biol 29 47-53

[10] Raucci J(2005)11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons J Nucl Med 46 484-494

[1] Mansour A(1988)Anatomy of CNS opioid receptors Trends Neurosci 11 308-314

[2] Khachaturian H(2008)Imaging of opioid receptors in the central nervous system Brain 131 1171-1196

[3] Lewis ME(1995)Kappa opioid inhibition of morphine and cocaine self-administration in rats Brain Res 681 147-152

[4] Akil H(2009)Natural products as tools for neuroscience: discovery and development of novel agents to treat drug abuse J Nat Prod 72 581-587

[5] Watson SJ(2001)Mu-, delta- and kappa-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer’s disease patients Brain Res 893 121-134

[6] Henriksen G(1999)Region-specific changes in prodynorphin mRNA and ir-dynorphin A levels after kindled seizures J Mol Neurosci 13 69-75

[7] Willoch F(1993)A potent new class of kappa-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines J Med Chem 36 2075-2083

[8] Glick SD(1999)[11C]-methyl 4-[(3, 4-dichlorophenyl)acetyl]-3-[(1-pyrrolidinyl)-methyl]-1- piperazinecarboxylate ([11C]GR89696): synthesis and in vivo binding to kappa opiate receptors Nucl Med Biol 26 737-741

[9] Maisonneuve IM(2002)[(11)C]-GR89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers Nucl Med Biol 29 47-53

[10] Raucci J(2005)11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons J Nucl Med 46 484-494