Synthesis and molecular docking studies of novel 1,2,3-triazole ring-containing 4-(1,4,5-triphenyl-1H-imidazol-2-yl)phenol derivatives as COX inhibitors

被引：0
作者：
B. Sathish Kumar
P. V. Anantha Lakshmi
机构：
[1] Osmania University,Department of Chemistry
来源：
Research on Chemical Intermediates | 2018年 / 44卷
关键词：
Cyclooxygenase; Imidazole; 1,2,3-Triazole; Chalcone; Docking studies;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of novel 3-phenyl-1-(4-(4-((4-(1,4,5-triphenyl-1H-imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)prop-2-en-1-one derivatives 6a–j were synthesized in click chemistry reaction conditions and evaluated in silico by docking studies to recognize their hypothetical binding motif with cyclooxygenase-1 and cyclooxygenase-2. All docked compounds exhibited good docking scores in the range from 208.357 to 161.285 as compared with 145.934 for indomethacin, and 168.763 to 147.904 as compared with 145.934 for ibuprofen. Among all the tested compounds, 6b showed good docking score and good interactions with binding-site residues of the COX proteins.
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页码：455 / 467
页数：12
相关论文
共 151 条
[1]  
Vane JR(1971)undefined Nat. New Biol. 231 232-undefined
[2]  
Sanda PD(2008)undefined Molecules 13 603-undefined
[3]  
Silva Lj D(2010)undefined Eur. J. Med. Chem. 45 2048-undefined
[4]  
Zorica DJ(2011)undefined Indian J. Chem. 50B 207-undefined
[5]  
Bojan DM(2007)undefined Bioorg. Med. Chem. 15 1083-undefined
[6]  
Sote MV(2010)undefined Res. J. Pharm. Biol. Chem. Sci. 1 23-undefined
[7]  
Ivan OJ(2008)undefined Bioorg. Med. Chem. Lett. 18 179-undefined
[8]  
Achar KCS(2013)undefined Res. Chem. Intermed. 39 1037-undefined
[9]  
Hosamani KM(2009)undefined Eur. J. Med. Chem. 44 4654-undefined
[10]  
Seetharamareddy HR(2011)undefined Eur. J. Med. Chem. 46 1926-undefined
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