Effects of Chronic Administration of Low-Dose Interleukin-1β on Exploratory Behavior and Spatial Memory in Rats

被引：0
作者：
Kalemenev S.V. [1 ]
Sizov V.V. [2 ]
Ishchenko A.M. [3 ]
Zubareva O.E. [2 ]
机构：
[1] Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg
[2] Institute of Experimental Medicine, St. Petersburg
[3] State Research Institute of Highly Pure Biopreparations, Federal Medical-Biological Agency, St. Petersburg
来源：
Neuroscience and Behavioral Physiology | 2016年 / 46卷 / 8期
关键词：
chronic administration; exploratory behavior; extinction; interleukin-1β; motor activity; spatial memory;
D O I：
10.1007/s11055-016-0330-x
中图分类号：
学科分类号：
摘要：
The actions of chronic i.p. administration of the proinflammatory cytokine interleukin-1β (IL-1β) on exploratory behavior and spatial memory were studied in rats. IL-1β was given at the weakly pyrogenic dose of 0.5 μg/kg daily for 14 days (starting seven days before and continuing through seven days of behavioral testing). Behavior was analyzed 23.5 h after sequential injections of cytokine. A battery of tests was used, including the open field test (on three sequential days), exploration of novel objects, and the Morris water maze. Experimental animals showed a significant decrease in motor activity, a minor increase in anxiety, and suppression of exploratory behavior. Impairments to spatial memory were not seen. © 2016, Springer Science+Business Media New York.
引用
收藏
页码：903 / 907
页数：4
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