50 Years of Barrett esophagus. Current diagnostic possibilities in the pathology [50 Jahre Barrett-Ösophagus. Aktuelle diagnostische möglichkeiten in der pathologie]

被引：0

作者：

Vieth M. ^{[1
]}

Seitz G. ^{[2
]}

机构：

[1] Institut für Pathologie, Klinikum Bayreuth

[2] Institut für Pathologie, Klinikum Bamberg

来源：

Der Pathologe | 2001年 / 22卷 / 1期

关键词：

Adenocarcinoma; Barrett's mucosa; Dysplasia; Immunohistochemistry; Molecular biology;

D O I：

10.1007/s002920000436

中图分类号：

学科分类号：

摘要：

The most important differential diagnosis of specialized intestinal columnar cell metaplasia (Barrett's-mucosa) is the intestinal metaplasia of the cardia mucosa (possibly caused by Helicobacter infection). Furthermore it happens from time to time that Barrett's regenerative epithelium is overdiagnosed as low-grade dysplasia (unequivocal intraepithelial neoplasia). This might explain the disappearance of many low-grade dysplasias during further follow-up. Mucosal adenocarcinomas are often underdiagnosed as dysplastic lesions. Therefore many authors tried to establish molecular methods for improvement of the diagnostic possiblities. Immunohistochemistry or PCR with p53 and HER 2-neu might give at least some help but a negative reaction does not exclude a neoplasia in every case. The gold standard is careful endoscopy and biopsy taking with good documentation of the endoscopical findings and most important still the routine H&E stain are the only reliable diagnostic tools.

引用

页码：62 / 71

页数：9

共 59 条

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