50 Years of Barrett esophagus. Current diagnostic possibilities in the pathology [50 Jahre Barrett-Ösophagus. Aktuelle diagnostische möglichkeiten in der pathologie]

被引：0
作者：
Vieth M. [1 ]
Seitz G. [2 ]
机构：
[1] Institut für Pathologie, Klinikum Bayreuth
[2] Institut für Pathologie, Klinikum Bamberg
来源：
Der Pathologe | 2001年 / 22卷 / 1期
关键词：
Adenocarcinoma; Barrett's mucosa; Dysplasia; Immunohistochemistry; Molecular biology;
D O I：
10.1007/s002920000436
中图分类号：
学科分类号：
摘要：
The most important differential diagnosis of specialized intestinal columnar cell metaplasia (Barrett's-mucosa) is the intestinal metaplasia of the cardia mucosa (possibly caused by Helicobacter infection). Furthermore it happens from time to time that Barrett's regenerative epithelium is overdiagnosed as low-grade dysplasia (unequivocal intraepithelial neoplasia). This might explain the disappearance of many low-grade dysplasias during further follow-up. Mucosal adenocarcinomas are often underdiagnosed as dysplastic lesions. Therefore many authors tried to establish molecular methods for improvement of the diagnostic possiblities. Immunohistochemistry or PCR with p53 and HER 2-neu might give at least some help but a negative reaction does not exclude a neoplasia in every case. The gold standard is careful endoscopy and biopsy taking with good documentation of the endoscopical findings and most important still the routine H&E stain are the only reliable diagnostic tools.
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页码：62 / 71
页数：9
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