5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: A case report

被引：11

作者：

McGlinchey P.G. ^{[1
]}

Webb S.T. ^{[1
]}

Campbell N.P.S. ^{[1
]}

机构：

[1] Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast BT12 6BA, Grosvenor Road

来源：

BMC Cardiovascular Disorders | / 1卷 / 1期

关键词：

Acute Myocardial Infarction; Ischaemic Heart Disease; Calcium Channel Antagonist; Electrocardiographic Change; Coronary Artery Spasm;

D O I：

10.1186/1471-2261-1-3

中图分类号：

学科分类号：

摘要：

Background: Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly understood. Case presentation: A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed. Electrocardiographs highlighting the severity of the presentation are included in the report along with coronary angiograms demonstrating the absence of significant coronary atherosclerosis. Conclusion: Severe 5-fluorouracil-induced cardiotoxicity is rare, but can be severe and may mimic acute myocardial infarction, leading to diagnostic and therapeutic dilemmas. Readministration of 5-fluorouracil is not advised following an episode of cardiotoxicity. © 2001 McGlinchey BioMed Central Ltd.

引用

共 9 条

[1]

Dent R.G., McColl I., 5 Fluorouracil and angina, Lancet, 1, pp. 347-348, (1975)

[2]

Pottage A., Holt S., Ludgate S., Langlands A.O., Fluorouracil cardiotoxicity, Br. Med. J., 1, (1978)

[3]

Stevenson D.L., Mikhailaidis D.P., Gillet D.S., Cardiotoxicity of 5 fluorouracil, Lancet, 2, pp. 406-407, (1977)

[4]

Ensley J.F., Patel B., Kloner R., Kish J.A., Wynne J., Al-Sarraf M., The clinical syndrome of 5-fluorouracil cardiotoxicity, Invest New Drugs, 7, pp. 101-109, (1989)

[5]

Keefe D.L., Roistacher N., Pierri M.K., Clinical cardiotoxicity of 5-fluorouracil, J. Clin. Pharmacol., 33, pp. 1060-1070, (1993)

[6]

Luwaert R.J., Descamps O., Majois F., Chaudron J.M., Beauduin M., Coronary artery spasm induced by 5-fluorouracil, Eur. Heart. J., 12, pp. 468-470, (1991)

[7]

Kleiman N.S., Lehane D.E., Geyer C.E., Pratt C.M., Young J.B., Prinzmetal's angina during 5-fluorouracil chemotherapy, Am. J. Med., 82, pp. 566-568, (1987)

[8]

Mizuno Y., Hokamura Y., Kimura T., Kimura Y., Kaikita K., Yasue H., A case of 5-fluorouracil cardiotoxicity simulating acute myocardial infarction, Jpn. Circ. J., 59, pp. 303-307, (1995)

[9]

Becker K., Erckenbrecht J.F., Haussinger D., Frieling T., Cardiotoxicity of the antiproliferative compound fluorouracil, Drugs, 57, pp. 475-484, (1999)

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