The full cohort of 512 patients and the nested controlled trial in 93 patients in the Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) study raise doubts about the effective size at present claimed

被引:0
作者
Tom Treasure
Norman R. Williams
Fergus Macbeth
机构
[1] University College London,Clinical Operational Research Unit
[2] University College London,Surgical and Interventional Trials Unit
[3] Cardiff University,Centre for Trials Research
来源
Journal of Cardiothoracic Surgery | / 17卷
关键词
Lung metastases; Colorectal cancer; Randomised controlled trial; PulMiCC trial; Prospective cohort study;
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摘要
A comparison of the relative merits of video-assisted pulmonary metastasectomy versus thoracotomy is predicated on the assumption that removal of asymptomatic lung metastases favourably influences survival and that it does so by a large degree. Recently published but long-awaited evidence from a prospective cohort study and a randomised trial of Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) challenges that assumption.
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