Enzymes catalyzed esterification of N-protected amino acids with secondary alcohols

被引：0

作者：

I.-L. Shih

L.-C. Chiu

C.T. Lai

W.-C. Liaw

D.-F. Tai

机构：

[1] Da-Yeh Institute of Technology,Biochemical Engineering Center

[2] National Yunlin Institute of Technology,Department of Chemical Engineering

[3] National Dong-Hwa University,Department of Chemistry

来源：

Biotechnology Letters | 1997年 / 19卷

关键词：

Enzyme; Alcohol; Ester; Organic Chemistry; Lipase;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Secondary alcohols were converted to their corresponding esters with N-Cbz-L-amino acids by Celite-immobilized protease or lipase in organic solvents at pH 7.5. The esterification of 2-butanol and 2-phenylethanol were achieved up to 71% yields. The optimal reaction condition for Aspergillus oryzae protease (AOP) catalyzed synthesis of N-Cbz-L-aspartyl- sec-butyl ester (97.6 de) was at pH 7.5 and a duration of 96 hours.

引用

页码：857 / 859

页数：2