Antimicrobial Peptides (AMPs): New Perspectives on Their Function in Dermatological Diseases

被引：1

作者：

Hsu, Chou-Yi ^{[1
,11
]}

Yousif, Aseel Muthana ^{[2
]}

Abullah, Khairia Abdulrahman ^{[3
]}

Abbas, Huda Hayder ^{[4
]}

Ahmad, Hijaz ^{[5
,6
,7
]}

Eldesoky, Gaber E. ^{[8
]}

Adil, Mohaned ^{[9
]}

Hussein, Zeanb ^{[10
]}

机构：

[1] Chia Nan Univ Pharm & Sci, Dept Pharm, Tainan 71710, Taiwan

[2] Univ Samarra, Coll Appl Sci, Dept Pathol Anal, Samarra, Iraq

[3] Al Noor Univ Coll, Dept Dent, Nineveh, Iraq

[4] Natl Univ Sci & Technol, Dhi Qar, Iraq

[5] Int Telemat Univ Uninettuno, Sect Math, Corso Vittorio Emanuele II 39, I-00186 Rome, Italy

[6] Gulf Univ Sci & Technol, Ctr Appl Math & Bioinformat, West Mishref, Kuwait

[7] Lebanese Amer Univ, Dept Comp Sci & Math, Beirut, Lebanon

[8] King Saud Univ, Coll Sci, Chem Dept, Riyadh 11451, Saudi Arabia

[9] Al Farahidi Univ, Pharm Coll, Baghdad, Iraq

[10] Al Zahrawi Univ Coll, Dept Pharm, Karbala, Iraq

[11] Arizona State Univ, Thunderbird Sch Global Management, Tempe Campus, Phoenix, AZ 85004 USA

来源：

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS | 2024年 / 30卷 / 03期

关键词：

Antimicrobial peptides; Skin-related diseases; Psoriasis; Atopic dermatitis; Cathelicidin; beta-defensin; BETA-DEFENSIN; 2; PLASMACYTOID DENDRITIC CELLS; DERMCIDIN-DERIVED PEPTIDES; INNATE IMMUNE-RESPONSE; HUMAN SKIN; CATHELICIDIN LL-37; ATOPIC-DERMATITIS; KOEBNERISIN S100A15; PSORIASIN S100A7; ALPHA-DEFENSINS;

D O I：

10.1007/s10989-024-10609-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimicrobial peptides (AMPs) are small cationic or amphipathic molecules that are produced by both prokaryotic and eukaryotic species. The latest findings in the field of dermatology point to the potential significance of AMPs in the battle against skin microbial infections. AMPs additionally function as multifunctional immune effectors, promoting angiogenesis, wound healing, and the production of cytokines and chemokines. In human skin, AMPs such as beta-defensin, S100, and cathelicidin are primarily secreted by keratinocytes, neutrophils, sebocytes, or sweat glands. These substances are either produced continuously or expressed in reaction to certain inflammatory stimuli, thus playing a role in the development of various skin diseases in humans. Furthermore, in contrast to other human skin conditions, the level of AMP synthesis decreases as the disease progresses. In this review, we provide data supporting the role of AMPs as natural mediators of dermatological problems, as well as their potential for being used as therapeutic agents in the treatment of skin diseases.

引用

页数：22

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