Effect of low-level laser therapy (685 nm, 3 J/cm2) on functional recovery of the sciatic nerve in rats following crushing lesion

被引：0
作者：
Mohammad Ashrafzadeh Takhtfooladi
Fatemeh Jahanbakhsh
Hamed Ashrafzadeh Takhtfooladi
Kambiz Yousefi
Amin Allahverdi
机构：
[1] Islamic Azad University,Young Researchers and Elites Club, Science and Research Branch
[2] University of Tehran,Department of Sports Injuries and Corrective Exercises, Faculty of Physical Education
[3] Islamic Azad University,Department of Pathology, Science and Research Branch
[4] Islamic Azad University,Department of Clinical Sciences, College of Veterinary Medicine, Karaj Branch
[5] Islamic Azad University,Department of Surgery, Science and Research Branch
来源：
Lasers in Medical Science | 2015年 / 30卷
关键词：
Photobiomodulation; Low-level laser; Sciatic functional index; Sciatic static index; Rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Previous studies have shown that low-level laser therapy (LLLT) promotes posttraumatic nerve regeneration. The objective of the present study was to assess the efficacy of 685-nm LLLT at the dosage of 3 J/cm2 in the functional recovery of the sciatic nerve in rats following crushing injury. The left sciatic nerves of 20 male Wistar rats were subjected to controlled crush injury by a hemostatic tweezers, and the rats were randomly allocated into two experimental groups as follows: control group and laser group. Laser irradiation (685 nm wavelength; 15 mW, CW, 3 J/cm2, spot of 0.028 cm2) was started on the postsurgical first day, above the site of injury, and was continued for 21 consecutive days. Functional recovery was evaluated at 3 weeks postoperatively by measuring the sciatic functional index (SFI) and sciatic static index (SSI) at weekly intervals. The treated rats showed improvement in motion pattern. The SFI and SSI results were significant when comparing two groups on the 14th and 21st postoperative days (p < 0.05). There were intra-group differences detected in laser group in different periods (p < 0.05). Low-level laser irradiation, with the parameters used in the present study, accelerated and improved sciatic nerve function in rats after crushing injury.
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页码：1047 / 1052
页数：5
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