The Peripheral Benzodiazepine Receptors: A Review

被引：0
|
作者：
Arnaud Beurdeley-Thomas
Laurent Miccoli
Stephane Oudard
Bernard Dutrillaux
Marie F. Poupon
机构：
[1] CNRS UMR 147,Laboratoire de Cytogénétique Moléculaire et Oncologie
[2] Institut Curie,Laboratoire de Génétique de la Radiosensibilité
[3] CEA Fontenay DSV/DRR/LGR,undefined
来源：
Journal of Neuro-Oncology | 2000年 / 46卷
关键词：
PBR; associated proteins; PRAX-1; cell differentiation; cancer; steroid biosynthesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Peripheral benzodiazepine receptors (PBRs) have been identified in various peripheral tissues as well as in glial cells in the brain. This review describes the tissue and subcellular distribution of the PBR in mammalian tissues and analyzes its many putative endogenous ligands. It deals with the pharmacological, structural and molecular characterization of the PBR, the proteins associated with the receptor (VDAC, ANC, PRAX-1) and their roles in cell growth and differentiation, cancer, steroid biosynthesis, and other physiological roles.
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页码：45 / 56
页数：11
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