The Peripheral Benzodiazepine Receptors: A Review

被引：0
|
作者：
Arnaud Beurdeley-Thomas
Laurent Miccoli
Stephane Oudard
Bernard Dutrillaux
Marie F. Poupon
机构：
[1] CNRS UMR 147,Laboratoire de Cytogénétique Moléculaire et Oncologie
[2] Institut Curie,Laboratoire de Génétique de la Radiosensibilité
[3] CEA Fontenay DSV/DRR/LGR,undefined
来源：
Journal of Neuro-Oncology | 2000年 / 46卷
关键词：
PBR; associated proteins; PRAX-1; cell differentiation; cancer; steroid biosynthesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Peripheral benzodiazepine receptors (PBRs) have been identified in various peripheral tissues as well as in glial cells in the brain. This review describes the tissue and subcellular distribution of the PBR in mammalian tissues and analyzes its many putative endogenous ligands. It deals with the pharmacological, structural and molecular characterization of the PBR, the proteins associated with the receptor (VDAC, ANC, PRAX-1) and their roles in cell growth and differentiation, cancer, steroid biosynthesis, and other physiological roles.
引用
收藏
页码：45 / 56
页数：11
相关论文
共 50 条
  • [21] Suicide attempters, stress and peripheral benzodiazepine receptors
    Catena, M.
    Baroni, S.
    Masala, I.
    Dell'Osso, B.
    Baldini, A.
    Giannaccini, G.
    Marazziti, D.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2006, 16 : S561 - S561
  • [22] PERIPHERAL BENZODIAZEPINE RECEPTORS IN PLATELETS OF EPILEPTIC PATIENTS
    LARKIN, JG
    MCKEE, PJW
    THOMPSON, GG
    BRODIE, MJ
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1993, 36 (01) : 71 - 74
  • [23] Peripheral benzodiazepine receptors on platelets of fibromyalgic patients
    Bazzichi, L.
    Giannaccini, G.
    Betti, L.
    Italiani, P.
    Fabbrini, L.
    Defeo, F.
    Giacomelli, C.
    Giuliano, T.
    Rossi, A.
    Uccelli, A.
    Giusti, L.
    Mascia, G.
    Lucacchini, A.
    Bombardieri, S.
    CLINICAL BIOCHEMISTRY, 2006, 39 (09) : 867 - 872
  • [24] Synthesis and evaluation of a trace for peripheral benzodiazepine receptors
    Li Bin
    Li Jian-Feng
    Fu Lei
    Sun Xiao-Guang
    Liu Jian-Jun
    Huang Gang
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2008, 29 (01): : 86 - 89
  • [25] Abnormal peripheral benzodiazepine receptors in social phobia
    Johnson, MR
    Marazziti, D
    Lydiard, RB
    Diamond, BI
    BIOLOGICAL PSYCHIATRY, 1996, 39 (07) : 316 - 316
  • [26] Bipolar disorder alters peripheral benzodiazepine receptors
    Baroni, S.
    Masala, I.
    Giannaccini, G.
    Catena, M.
    Bevilacqua, L.
    Dell'Osso, B.
    Marazziti, D.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2006, 16 : S570 - S570
  • [27] PERIPHERAL-TYPE BENZODIAZEPINE RECEPTORS IN HUMAN PROSTATE
    ESCUBEDO, E
    CAMINS, A
    TRESSERRA, F
    ADZET, T
    CAMARASA, J
    PHARMACOLOGY, 1993, 46 (02) : 115 - 120
  • [28] Expression of peripheral benzodiazepine receptors in human skin.
    Stoebner, PE
    Carayon, P
    Penarier, G
    Frechin, N
    Barneon, G
    Casellas, P
    Dussossoy, D
    Cano, JP
    Meynadier, J
    Meunier, B
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1997, 108 (05) : C15 - C15
  • [29] PERIPHERAL AND CENTRAL TYPE BENZODIAZEPINE RECEPTORS IN MAUDSLEY RATS
    TAMBORSKA, E
    INSEL, T
    MARANGOS, PJ
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 126 (03) : 281 - 287
  • [30] CHARACTERIZATION OF PORPHYRIN INTERACTIONS WITH PERIPHERAL TYPE BENZODIAZEPINE RECEPTORS
    VERMA, A
    SNYDER, SH
    MOLECULAR PHARMACOLOGY, 1988, 34 (06) : 800 - 805
12345