Genetic polymorphism and natural selection of the erythrocyte binding antigen 175 region II in Plasmodium falciparum populations from Myanmar and Vietnam

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作者
Tuấn Cường Võ
Hương Giang Lê
Jung-Mi Kang
Haung Naw
Won Gi Yoo
Moe Kyaw Myint
Huynh Hong Quang
Byoung-Kuk Na
机构
[1] Gyeongsang National University College of Medicine,Department of Parasitology and Tropical Medicine, and Institute of Health Science
[2] Gyeongsang National University,Department of Convergence Medical Science
[3] Department of Medical Research Pyin Oo Lwin Branch,undefined
[4] Tropical Diseases Clinical and Treatment Research Department,undefined
[5] Institute of Malariology,undefined
[6] Parasitology,undefined
[7] and Entomology Quy Nhon,undefined
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Plasmodium falciparum erythrocyte binding antigen 175 (PfEBA-175) plays essential role in erythrocyte invasion by the parasite and is a leading vaccine candidate. However, its genetic diversity in global isolates is a concern in developing an universal vaccine incorporating this protein. This study aimed to investigate genetic polymorphisms and natural selection of pfeba-175 region II (RII) in Myanmar and Vietnam P. falciparum isolates. Vietnam pfeba-175 RII displayed a low genetic polymorphism, while Myanmar pfeba-175 RII showed high levels of genetic diversity across the region. Point mutations, deletion, and recombinations were main factors contributing to genetic diversities in P. falciparum populations. Global pfeba-175 RII revealed similar, but not identical, genetic polymorphisms and natural selection profiles. Despite profiles of amino acid substitutions differed among populations, five major amino acid changes (K279E, E403K, K481I, Q584K, and R664) were commonly detected in global pfeba-175 RII populations. Haplotype network and genetic differentiation analyses of global pfeba-175 RII populations demonstrated no geographical relationships. Non-neglectable level of genetic diversity was observed in global pfeba-175 RII populations, emphasizing the need to consider this when designing an effective vaccine based on this protein. This study underscores the importance of the continuous monitoring of genetic diversity of pfeba-175 RII in the global P. falciparum populations.
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