Immune therapy for type 1 diabetes mellitus—what is unique about anti-CD3 antibodies?

被引：0
|
作者：
Lucienne Chatenoud
机构：
[1] Université Paris Descartes,
[2] INSERM U1013,undefined
[3] Hôpital Necker Enfants Malades,undefined
来源：
Nature Reviews Endocrinology | 2010年 / 6卷
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摘要：
Immune therapies that induce or, in the case of established type 1 diabetes mellitus (T1DM), restore immune tolerance to target autoantigens hold potential to cure T1DM whilst avoiding the need for chronic immunosuppression. This Review discusses different immune therapies for T1DM and, in particular, focuses on two promising strategies in clinical development—the use of candidate autoantigens and anti-CD3 monoclonal antibodies—that aim to restore immune tolerance.
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页码：149 / 157
页数：8
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