The Synthesis of Cholesterol-Containing Cationic Amphiphils with Heterocyclic Bases

被引：0
|
作者：
T. V. Konstantinova
V. N. Klykov
G. A. Serebrennikova
机构：
[1] Lomonosov State Academy of Fine Chemical Technology,
来源：
Russian Journal of Bioorganic Chemistry | 2001年 / 27卷
关键词：
cholesterol cationic derivatives; transfection;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A number of cationic derivatives of cholesterol containing polar residues of N-methylimidazole, pyridine, N-methylmorpholine, and 4-N,N-dimethyaminopyridine were synthesized by the interaction of the corresponding heterocyclic bases with cholesterol 5-bromopentanoate followed by the treatment with methyl iodide in the case of tertiary amines. In addition, N-(4-cholesteryloxycarbonylbutyl)piperazine was obtained for the preparation of pH-sensitive liposomes.
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页码：404 / 407
页数：3
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