A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia

被引：0

作者：

J Williams

G Spurlock

P Holmans

R Mant

K Murphy

L Jones

A Cardno

P Asherson

D Blackwood

W Muir

K Meszaros

H Aschauer

J Mallet

C Laurent

P Pekkarinen

J Seppala

C N Stefanis

G N Papadimitriou

F Macciardi

M Verga

C Pato

H Azevedo

M-A Crocq

H Gurling

G Kalsi

D Curtis

P McGuffin

M J Owen

机构：

[1] University of Wales College of Medicine,Department of Psychological Medicine

[2] Heath Park,Department of Clinical Opthalmology

[3] Institute of Medical Genetics,Department of Psychiatry

[4] University of Wales College of Medicine,Department of General Psychiatry

[5] Heath Park,Departments of Human Molecular Genetics and Mental Health

[6] The Institute of Opthalmology and Moorfields Eye Hospital,Department of Psychiatry

[7] Institute of Psychiatry,Department of Neuroscience

[8] De Crespigny Park,Department of Psychiatry and Behavioural Sciences

[9] The University of Edinburgh,undefined

[10] Kennedy Tower,undefined

[11] Royal Edinburgh Hospital,undefined

[12] Morningside Park,undefined

[13] University Hospital for Psychiatry,undefined

[14] Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneraties,undefined

[15] CNRS-LGN,undefined

[16] Batiment CERVI,undefined

[17] National Public Health Institute,undefined

[18] Athens University Medical School,undefined

[19] Eginition Hospital,undefined

[20] Istituto Scientifico H San Raffaele,undefined

[21] University of Milano – School of Medicine,undefined

[22] Centre for Neuroscience,undefined

[23] Universidade de Coimbra,undefined

[24] Foundation for Applied Neuroscience,undefined

[25] Research in Psychiatry,undefined

[26] Molecular Psychiatry Laboratory,undefined

[27] Windeyer Institute for Medical Science,undefined

[28] University College London Medical School,undefined

来源：

Molecular Psychiatry | 1998年 / 3卷

关键词：

D3 receptor gene; meta-analysis; TDT; schizophrenia; association;

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学科分类号：

摘要：

We performed a meta-analysis of over 30 case-control studies of association between schizophrenia and a bi-allelic, BalI polymorphism in exon 1 of the dopamine D3 receptor gene. We observed a significant excess of both forms of homozygote in patients (P = 0.0009, odds ratio (OR) = 1.21, 95% Confidence Interval (CI) = 1.07–1.35) in the combined sample of 5351 individuals. No significant heterogeneity was detected between samples and the effects did not appear to be the product of publishing bias. In addition we undertook an independent, family-based association study of this polymorphism in 57 parent/proband trios, taken from unrelated European multiplex families segregating schizophrenia. A transmission disequilibrium test (TDT) showed a significant excess of homozygotes in schizophrenic patients (P = 0.004, odds ratio (OR) = 2.7, 95% CI = 1.35–5.86). Although no significant allelic association was observed, a significant association was detected with the 1–1 genotype alone (P = 0.02, OR = 2.32, 95% CI = 1.13–4.99). In addition when the results of the family-based association study were included in the meta-analysis, the homozygosity effect increased in significance (P = 0.0002, OR = 1.23, 95% CI = 1.09–1.38). The results of the meta-analysis and family-based association study provide independent support for a relationship between schizophrenia and homozygosity at the BalI polymorphism of the D3 receptor gene, or between a locus in linkage disequilibrium with it.

引用

页码：141 / 149

页数：8